Tomoko Oya-Ito
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Explore the profile of Tomoko Oya-Ito including associated specialties, affiliations and a list of published articles.
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22
Citations
292
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Recent Articles
11.
Okada H, Naito Y, Takagi T, Takaoka M, Oya-Ito T, Fukumoto K, et al.
J Clin Biochem Nutr
. 2012 Jan;
50(1):47-52.
PMID: 22247600
N(ε)-(Hexanoyl)lysine, formed by the reaction of lysine with n-6 lipid hydroperoxide, is a lipid peroxidation marker during the initial stage of oxidative stress. The aim of the present study is...
12.
Oya-Ito T, Naito Y, Takagi T, Handa O, Matsui H, Yamada M, et al.
Biochim Biophys Acta
. 2011 Apr;
1812(7):769-81.
PMID: 21497196
The molecular mechanisms underlying the posttranslational modification of proteins in gastrointestinal cancer are still unknown. Here, we investigated the role of methylglyoxal modifications in gastrointestinal tumors. Methylglyoxal is a reactive...
13.
Takagi T, Naito Y, Okada H, Okayama T, Mizushima K, Yamada S, et al.
J Clin Biochem Nutr
. 2011 Mar;
48(2):178-82.
PMID: 21373273
Previous studies have shown that activated neutrophils and their myeloperoxidase (MPO)-derived products play a crucial role in the pathogenesis of non-steroidal anti-inflammatory drug (NSAID)-related small intestinal injury. The aim of...
14.
Nagaraj R, Biswas A, Miller A, Oya-Ito T, Bhat M
Ann N Y Acad Sci
. 2008 May;
1126:107-12.
PMID: 18448802
The Maillard reaction plays an important role in eye lens aging and cataract formation. Methylglyoxal (MGO) is a metabolic dicarbonyl compound present in the lens. It reacts with arginine residues...
15.
Oya-Ito T, Naitou H, Masuda S, Kinae N, Ohashi N
Mol Nutr Food Res
. 2008 Feb;
52(3):360-9.
PMID: 18293300
Diabetic patients are prone to severe bacterial infections. The functional alterations of neutrophils by hyperglycemia are thought to be partially responsible for such infections. In this study, we investigated the...
16.
Oya-Ito T, Liu B, Nagaraj R
J Cell Biochem
. 2006 Apr;
99(1):279-91.
PMID: 16615138
Heat shock protein 27 (Hsp27) is a stress-inducible protein in cells that functions as a molecular chaperone and also as an anti-apoptotic protein. Methylglyoxal (MGO) is a reactive dicarbonyl compound...
17.
Biswas A, Miller A, Oya-Ito T, Santhoshkumar P, Bhat M, Nagaraj R
Biochemistry
. 2006 Apr;
45(14):4569-77.
PMID: 16584192
We reported previously that chemical modification of human alphaA-crystallin by a metabolic dicarbonyl compound, methylglyoxal (MGO), enhances its chaperone-like function, a phenomenon which we attributed to formation of argpyrimidine at...
18.
Puttaiah S, Zhang Y, Pilch H, Pfahler C, Oya-Ito T, Sayre L, et al.
Arch Biochem Biophys
. 2006 Jan;
446(2):186-96.
PMID: 16406213
Glycation or the Maillard reaction in proteins forms advanced glycation end products (AGEs) that contribute to age- and diabetes-associated changes in tissues. Dideoxyosones, which are formed by the long-range carbonyl...
19.
Nagaraj R, Oya-Ito T, Bhat M, Liu B
Ann N Y Acad Sci
. 2005 Jul;
1043:158-65.
PMID: 16037235
Methylglyoxal (MGO) is an alpha-dicarbonyl compound produced from triose phosphate intermediates of glycolysis. It reacts rapidly with proteins to produce advanced glycation products. We have studied the effect of MGO...
20.
Nagaraj R, Oya-Ito T, Padayatti P, Kumar R, Mehta S, West K, et al.
Biochemistry
. 2003 Sep;
42(36):10746-55.
PMID: 12962499
The molecular chaperone function of alpha-crystallin in the lens prevents the aggregation and insolubilization of lens proteins that occur during the process of aging. We found that chemical modification of...