Alpha 2.0
Login Register
» Authors » Tomoko Chiyo

Tomoko Chiyo

Explore the profile of Tomoko Chiyo including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 12
Citations 207
Followers 0
Related Specialties
Science
Molecular Biology
General Medicine
Top 10 Co-Authors
Takashi Okada
Shinichi Takeda
Hiromi Hayashita-Kinoh
Yuko Nitahara-Kasahara
Hironori Okada
Tatsushi Toda
Chiyomi Ito
Motoi Kanagawa
Chih-Chieh Yu
Yoshihisa Ohtsuka
Published In
Hum Mol Genet
Mol Ther Nucleic Acids
PLoS One
Endocrinology
Mol Ther
Affiliations
Soon will be listed here.
Recent Articles
1.
Improved transduction of canine X-linked muscular dystrophy with rAAV9-microdystrophin via multipotent MSC pretreatment
Hayashita-Kinoh H, Guillermo P, Nitahara-Kasahara Y, Kuraoka M, Okada H, Chiyo T, et al.
Mol Ther Methods Clin Dev . 2021 Jan; 20:133-141. PMID: 33426145
Duchenne muscular dystrophy (DMD) is a severe congenital disease associated with mutation of the dystrophin gene. Supplementation of dystrophin using recombinant adeno-associated virus (rAAV) has promise as a treatment for...
2.
Supplemental Treatment for Huntington's Disease with miR-132 that Is Deficient in Huntington's Disease Brain
Fukuoka M, Takahashi M, Fujita H, Chiyo T, Popiel H, Watanabe S, et al.
Mol Ther Nucleic Acids . 2018 Jun; 11:79-90. PMID: 29858092
Huntington's disease (HD) is an intractable neurodegenerative disorder caused by mutant Huntingtin (HTT) proteins that adversely affect various biomolecules and genes. MicroRNAs (miRNAs), which are functional small non-coding RNAs, are...
3.
Fukutin is prerequisite to ameliorate muscular dystrophic phenotype by myofiber-selective LARGE expression
Ohtsuka Y, Kanagawa M, Yu C, Ito C, Chiyo T, Kobayashi K, et al.
Sci Rep . 2015 Feb; 5:8316. PMID: 25661440
α-Dystroglycanopathy (α-DGP) is a group of muscular dystrophy characterized by abnormal glycosylation of α-dystroglycan (α-DG), including Fukuyama congenital muscular dystrophy (FCMD), muscle-eye-brain disease, Walker-Warburg syndrome, and congenital muscular dystrophy type...
4.
Intra-amniotic rAAV-mediated microdystrophin gene transfer improves canine X-linked muscular dystrophy and may induce immune tolerance
Hayashita-Kinoh H, Yugeta N, Okada H, Nitahara-Kasahara Y, Chiyo T, Okada T, et al.
Mol Ther . 2015 Jan; 23(4):627-37. PMID: 25586688
Duchenne muscular dystrophy (DMD) is a severe congenital disease due to mutations in the dystrophin gene. Supplementation of dystrophin using recombinant adenoassociated virus vector has promise as a treatment of...
5.
Neuromuscular disease. DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction
Arimura S, Okada T, Tezuka T, Chiyo T, Kasahara Y, Yoshimura T, et al.
Science . 2014 Sep; 345(6203):1505-8. PMID: 25237101
The neuromuscular junction (NMJ) is the synapse between a motor neuron and skeletal muscle. Defects in NMJ transmission cause muscle weakness, termed myasthenia. The muscle protein Dok-7 is essential for...
6.
Dystrophic mdx mice develop severe cardiac and respiratory dysfunction following genetic ablation of the anti-inflammatory cytokine IL-10
Nitahara-Kasahara Y, Hayashita-Kinoh H, Chiyo T, Nishiyama A, Okada H, Takeda S, et al.
Hum Mol Genet . 2014 Mar; 23(15):3990-4000. PMID: 24659498
Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease that causes respiratory and cardiac failure. Inflammation is a key pathological characteristic of dystrophic muscle lesion formation, but its role and...
7.
Specific inhibition of tumor cells by oncogenic EGFR specific silencing by RNA interference
Takahashi M, Chiyo T, Okada T, Hohjoh H
PLoS One . 2013 Aug; 8(8):e73214. PMID: 23951344
Anticancer agents that have minimal effects on normal cells and tissues are ideal cancer drugs. Here, we show specific inhibition of human cancer cells carrying oncogenic mutations in the epidermal...
8.
Robust Long-term Transduction of Common Marmoset Neuromuscular Tissue With rAAV1 and rAAV9
Okada H, Ishibashi H, Hayashita-Kinoh H, Chiyo T, Nitahara-Kasahara Y, Baba Y, et al.
Mol Ther Nucleic Acids . 2013 May; 2:e95. PMID: 23715217
Profiles of recombinant adeno-associated virus (rAAV)-mediated transduction show interspecies differences for each AAV serotype. Robust long-term transgene expression is generally observed in rodents, whereas insufficient transduction is seen in animals...
9.
Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression
Kanagawa M, Yu C, Ito C, Fukada S, Hozoji-Inada M, Chiyo T, et al.
Hum Mol Genet . 2013 Apr; 22(15):3003-15. PMID: 23562821
A group of muscular dystrophies, dystroglycanopathy is caused by abnormalities in post-translational modifications of dystroglycan (DG). To understand better the pathophysiological roles of DG modification and to establish effective clinical...
10.
Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver
Sekiguchi S, Kimura K, Chiyo T, Ohtsuki T, Tobita Y, Tokunaga Y, et al.
PLoS One . 2013 Jan; 7(12):e51656. PMID: 23284733
Chronic hepatitis C, which is caused by infection with the hepatitis C virus (HCV), is a global health problem. Using a mouse model of hepatitis C, we examined the therapeutic...