Tomoki Okazaki
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Explore the profile of Tomoki Okazaki including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
279
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Recent Articles
1.
Okudaira N, Akimoto M, Susa T, Akimoto M, Hisaki H, Iizuka M, et al.
Aging Cell
. 2024 May;
23(9):e14206.
PMID: 38769821
Aging progresses through the interaction of metabolic processes, including changes in the immune and endocrine systems. Glucocorticoids (GCs), which are regulated by the hypothalamic-pituitary-adrenal (HPA) axis, play an important role...
2.
Akimoto M, Susa T, Okudaira N, Koshikawa N, Hisaki H, Iizuka M, et al.
Proc Natl Acad Sci U S A
. 2023 Apr;
120(18):e2218033120.
PMID: 37094129
As a decoy receptor, soluble ST2 (sST2) interferes with the function of the inflammatory cytokine interleukin (IL)-33. Decreased sST2 expression in colorectal cancer (CRC) cells promotes tumor growth via IL-33-mediated...
3.
Akimoto M, Susa T, Okudaira N, Hisaki H, Iizuka M, Okinaga H, et al.
J Biol Chem
. 2022 May;
298(7):102065.
PMID: 35618021
Long noncoding RNAs (lncRNAs) are important tissue-specific regulators of gene expression, and their dysregulation can induce aberrant gene expression leading to various pathological conditions, including cancer. Although many lncRNAs have...
4.
Kikuyama T, Susa T, Tamamori-Adachi M, Iizuka M, Akimoto M, Okinaga H, et al.
J Steroid Biochem Mol Biol
. 2020 Jan;
199:105593.
PMID: 31945466
Recently, it was reported that 25(OH)D (25D3) has physiological bioactivity in certain tissues derived from Cyp27b1 knockout mice. To investigate the function of 25D3 in the kidney as an informational...
5.
Tamamori-Adachi M, Koga A, Susa T, Fujii H, Tsuchiya M, Okinaga H, et al.
Sci Rep
. 2018 Jun;
8(1):9636.
PMID: 29941883
Glucocorticoid production is regulated by adrenocorticotropic hormone (ACTH) via the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway in the adrenal cortex, but the changes in steroidogenesis associated with aging...
6.
Susa T, Iizuka M, Okinaga H, Tamamori-Adachi M, Okazaki T
Sci Rep
. 2018 Jun;
8(1):9024.
PMID: 29899561
Recently, the antiproliferative action of 1,25(OH)D (1,25D3), an active metabolite of vitamin D, in the management of prostate cancer has been argued rigorously. In this study, we found that at...
7.
Maeba R, Kojima K, Nagura M, Komori A, Nishimukai M, Okazaki T, et al.
Atherosclerosis
. 2018 Feb;
270:102-109.
PMID: 29407877
Background And Aim: Current research suggests that dysfunctional high-density lipoprotein (HDL) with low cholesterol efflux capacity may accelerate atherosclerosis, particularly in chronic kidney disease (CKD). We previously reported that serum...
8.
Uchida K, Tanaka Y, Ichikawa H, Watanabe M, Mitani S, Morita K, et al.
J Endocr Soc
. 2017 Dec;
1(6):691-711.
PMID: 29264523
Thus far, only 23 cases of the ectopic production of parathyroid hormone (PTH) have been reported. We have characterized the genome-wide transcription profile of an ectopic PTH-producing tumor originating from...
9.
Iizuka M, Susa T, Tamamori-Adachi M, Okinaga H, Okazaki T
Proc Jpn Acad Ser B Phys Biol Sci
. 2017 Aug;
93(7):498-510.
PMID: 28769019
Estrogen receptors (ER) are important transcription factors to relay signals from estrogen and to regulate proliferation of some of breast cancers. The cycling of estrogen-induced DNA binding and ubiquitin-linked proteolysis...
10.
Nakakura T, Suzuki T, Torii S, Asano-Hoshino A, Nekooki-Machida Y, Tanaka H, et al.
Cell Tissue Res
. 2017 Jul;
370(1):169-178.
PMID: 28687926
The production and secretion of adrenocorticotropin, a proopiomelanocortin (POMC)-derived hormone, by corticotrophs in the anterior pituitary, is regulated by corticotrophin-releasing hormone (CRH) and glucocorticoids. We have previously demonstrated that adrenalectomy...