Tomohiro Kabuta
Overview
Explore the profile of Tomohiro Kabuta including associated specialties, affiliations and a list of published articles.
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55
Citations
7159
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Recent Articles
1.
Fujiwara Y, Oroku K, Zhou Y, Takahashi M, Katayama T, Wada K, et al.
RNA Biol
. 2024 Jan;
21(1):1-9.
PMID: 38200692
Double-stranded RNA (dsRNA) is a molecular pattern uniquely produced in cells infected with various viruses as a product or byproduct of replication. Cells detect such molecules, which indicate non-self invasion,...
2.
Contu V, Sakai R, Fujiwara Y, Kabuta C, Wada K, Kabuta T
Biochem Biophys Res Commun
. 2023 Jan;
644:105-111.
PMID: 36640664
RNautophagy/DNautophagy (RDA) is an autophagic process that refers to the direct uptake of nucleic acids by lysosomes for degradation. Autophagy relies on lysosomes and lysosomal acidification is crucial for the...
3.
Takahashi M, Seki M, Nashimoto M, Kabuta T
J Nucleic Acids
. 2021 Nov;
2021:2458470.
PMID: 34824869
Although antisense oligonucleotide (ASO) therapeutics can be taken up by living cells without carrier molecules, a large part of incorporated ASOs are trapped in the endosomes and do not exert...
4.
Fujiwara Y, Kabuta C, Sano T, Murayama S, Saito Y, Kabuta T
Neurochem Int
. 2021 Nov;
152:105243.
PMID: 34800582
Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are major neurodegenerative disorders that share commonalities in their pathology involving the formation of Lewy bodies, the main component of which...
5.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
6.
Nishikawa R, Osaki M, Sasaki R, Ishikawa M, Yumioka T, Yamaguchi N, et al.
Oncol Rep
. 2020 Sep;
44(5):1810-1820.
PMID: 32901843
Sunitinib, a tyrosine kinase inhibitor, is among the first‑line treatments for metastatic or advanced stage renal cell carcinoma (RCC). However, patients with RCC develop resistance to sunitinib. We have previously...
7.
Hase K, Contu V, Kabuta C, Sakai R, Takahashi M, Kataoka N, et al.
Autophagy
. 2020 Jan;
16(11):1974-1988.
PMID: 31944164
RNautophagy and DNautophagy (RDA) are unconventional autophagic pathways where nucleic acids are directly transported through the lysosomal membrane, then degraded inside lysosomes. We have previously shown that bitopic protein LAMP2C...
8.
Hirayama K, Fujiwara Y, Terada T, Shimizu K, Wada K, Kabuta T
Neurochem Int
. 2019 Mar;
126:19-26.
PMID: 30831216
Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease caused by selective motor neuron death. Mutations in the gene encoding copper/zinc superoxide dismutase (SOD1) belong to one of the four...
9.
Contu V, Hase K, Kozuka-Hata H, Oyama M, Fujiwara Y, Kabuta C, et al.
J Cell Sci
. 2017 Jul;
130(17):2843-2853.
PMID: 28724756
RNA degradation is an essential process for maintaining cellular homeostasis. Previously, we discovered a novel RNA degradation system, RNautophagy, during which direct import of RNA into lysosomes in an ATP-dependent...
10.
Takahashi M, Contu V, Kabuta C, Hase K, Fujiwara Y, Wada K, et al.
RNA Biol
. 2017 Mar;
14(11):1534-1543.
PMID: 28277980
Single-stranded oligonucleotides (ssOligos) are efficiently taken up by living cells without the use of transfection reagents. This phenomenon called 'gymnosis' enables the sequence-specific silencing of target genes in various types...