Tomasz Grabowski
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Explore the profile of Tomasz Grabowski including associated specialties, affiliations and a list of published articles.
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Articles
77
Citations
182
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Recent Articles
1.
Szkutnik-Fiedler D, Karbownik A, Otto F, Maciejewska J, Kuznik A, Grabowski T, et al.
Pharmaceutics
. 2025 Jan;
16(12.
PMID: 39771554
Background: Olaparib (OLA) and regorafenib (REG) are metabolized by the CYP3A4 isoenzyme of cytochrome P450. Both drugs are also substrates and inhibitors of the membrane transporters P-glycoprotein and BCRP. Therefore,...
2.
Karbownik A, Szkutnik-Fiedler D, Otto F, Wolc A, Grabowski T, Maciejewska Z, et al.
Pharmaceutics
. 2024 Nov;
16(11).
PMID: 39598511
: In clinical practice, the prevalent problem of polypharmacy could result in increased risks of drug-drug interactions. Regorafenib (REG) is commonly co-administered with paracetamol (PA) as a treatment protocol in...
3.
Miedziaszczyk M, Karczewski M, Grabowski T, Wolc A, Idasiak-Piechocka I
Front Pharmacol
. 2024 Apr;
15:1352323.
PMID: 38638867
Tacrolimus is metabolized in the liver with the participation of the CYP3A4 and CYP3A5 enzymes. Proton pump inhibitors are used in kidney transplant patients to prevent duodenal and gastric ulcer...
4.
Stanislawiak-Rudowicz J, Karbownik A, Szkutnik-Fiedler D, Otto F, Grabowski T, Wolc A, et al.
Cancer Chemother Pharmacol
. 2023 Oct;
93(1):79-88.
PMID: 37815561
Objective: Olaparib is a PARP (poly-ADP-ribose polymerase) inhibitor used for maintenance therapy in BRCA-mutated cancers. Metformin is a first-choice drug used in the treatment of type 2 diabetes. Both drugs...
5.
Grabowski T, Derlacz R, Burmanczuk A
Biomed Pharmacother
. 2022 Oct;
156:113926.
PMID: 36308917
Natalizumab is a recombinant, humanized form of a monoclonal antibody that binds to CD49d. The presented study was conducted to explore the suitability of Göttingen pigs as a pharmacokinetic/pharmacodynamic model...
6.
Zygmuntowicz A, Markiewicz W, Grabowski T, Jaroszewski J
J Vet Res
. 2022 Jul;
66(2):257-265.
PMID: 35892107
Introduction: Bisphenols, as endocrine disruptors, may cause a wide range of health problems in humans, but so far, not all of them have been confirmed in animals, including pigs. Since...
7.
Karbownik A, Szkutnik-Fiedler D, Grabowski T, Wolc A, Stanislawiak-Rudowicz J, Jazwiec R, et al.
Pharmaceutics
. 2021 Dec;
13(12).
PMID: 34959453
A combination of the tyrosine kinase inhibitor-sorafenib-and the opioid analgesic-morphine-can be found in the treatment of cancer patients. Since both are substrates of P-glycoprotein (P-gp), and sorafenib is also an...
8.
Grabowski T, Burmanczuk A, Derlacz R, Stefaniak T, Rzasa A, Borkowski J
J Vet Sci
. 2021 Aug;
22(5):e47.
PMID: 34423596
Background: Due to multiple similarities in the structure and physiology of human and pig skin, the pig model is extremely useful for biological drug testing after subcutaneous administration. Knowledge of...
9.
Kedzierska A, Lorek D, Slawek A, Grabowski T, Chelmonska-Soyta A
Int J Mol Sci
. 2021 Jul;
22(14).
PMID: 34298914
The loss of immune tolerance to fetal antigens may result in reproductive failure. The downregulated number and activity of T regulatory lymphocytes, which are critical for the establishment of immune...
10.
Zygmuntowicz A, Markiewicz W, Grabowski T, Burmanczuk A, Vyniarska A, Jaroszewski J
PLoS One
. 2021 Jul;
16(7):e0252438.
PMID: 34270573
Quercetin is a polyphenolic flavonoid occurring in leaves, stems, flowers and fruits of many plants. In traditional Chinese medicine, it is used as a natural therapeutic agent with a broad...