Tomasz Bzdega
Overview
Explore the profile of Tomasz Bzdega including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
511
Followers
0
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Recent Articles
1.
Olszewski R, Janczura K, Bzdega T, Der E, Venzor F, ORourke B, et al.
Neurochem Res
. 2017 Mar;
42(9):2646-2657.
PMID: 28285415
Glutamate carboxypeptidase II (GCPII) inactivates the peptide neurotransmitter N-acetylaspartylglutamate (NAAG) following synaptic release. Inhibitors of GCPII increase extracellular NAAG levels and are efficacious in animal models of clinical disorders via...
2.
Janczura K, Olszewski R, Bzdega T, Bacich D, Heston W, Neale J
Eur J Pharmacol
. 2012 Dec;
701(1-3):27-32.
PMID: 23200894
The peptide neurotransmitter N-acetylaspartylglutamate (NAAG) is inactivated by the extracellular enzyme glutamate carboxypeptidase II. Inhibitors of this enzyme reverse dizocilpine (MK-801)-induced impairment of short-term memory in the novel object recognition...
3.
Walder K, Ryan S, Bzdega T, Olszewski R, Neale J, Lindgren C
Eur J Neurosci
. 2012 Nov;
37(1):118-29.
PMID: 23134476
Immunohistochemical studies previously revealed the presence of the peptide transmitter N-acetylaspartylglutamate (NAAG) in spinal motor neurons, axons and presumptive neuromuscular junctions (NMJs). At synapses in the central nervous system, NAAG...
4.
Yamada T, Zuo D, Yamamoto T, Olszewski R, Bzdega T, Moffett J, et al.
Mol Pain
. 2012 Sep;
8:67.
PMID: 22971334
Background: Metabotropic glutamate receptors (mGluRs) have been identified as significant analgesic targets. Systemic treatments with inhibitors of the enzymes that inactivate the peptide transmitter N-acetylaspartylglutamate (NAAG), an mGluR3 agonist, have...
5.
Zuo D, Bzdega T, Olszewski R, Moffett J, Neale J
J Biol Chem
. 2012 May;
287(26):21773-82.
PMID: 22570482
The "glutamate" theory of schizophrenia emerged from the observation that phencyclidine (PCP), an open channel antagonist of the NMDA subtype of glutamate receptor, induces schizophrenia-like behaviors in humans. PCP also...
6.
Olszewski R, Bzdega T, Neale J
Schizophr Res
. 2012 Feb;
136(1-3):160-1.
PMID: 22300789
No abstract available.
7.
Neale J, Olszewski R, Zuo D, Janczura K, Profaci C, Lavin K, et al.
J Neurochem
. 2011 Jun;
118(4):490-8.
PMID: 21644997
A substantial body of data was reported between 1984 and 2000 demonstrating that the neuropeptide N-acetylaspartylglutamate (NAAG) not only functions as a neurotransmitter but also is the third most prevalent...
8.
Wroblewska B, Wegorzewska I, Bzdega T, Neale J
Neurochem Int
. 2010 Dec;
58(2):176-9.
PMID: 21115084
The group II metabotropic glutamate receptors 2 and 3 (mGluR2 and mGluR3) share sequence homology, common pharmacology and negative coupling to cAMP. We recently discovered that mGluR3 also is negatively...
9.
Yamamoto T, Saito O, Aoe T, Bartolozzi A, Sarva J, Zhou J, et al.
Eur J Neurosci
. 2007 Jan;
25(1):147-58.
PMID: 17241276
The peptide neurotransmitter N-acetylaspartylglutamate (NAAG) selectively activates group II metabotropic glutamate receptors (mGluRs). Systemic administration of inhibitors of the enzymes that inactivate NAAG results in decreased pain responses in rat...
10.
Zhong C, Zhao X, Van K, Bzdega T, Smyth A, Zhou J, et al.
J Neurochem
. 2006 Apr;
97(4):1015-25.
PMID: 16606367
Traumatic brain injury (TBI) produces a rapid and excessive elevation in extracellular glutamate that induces excitotoxic brain cell death. The peptide neurotransmitter N-acetylaspartylglutamate (NAAG) is reported to suppress neurotransmitter release...