Tomasz Ahrends
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Explore the profile of Tomasz Ahrends including associated specialties, affiliations and a list of published articles.
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14
Citations
1469
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Recent Articles
1.
Ahrends T, Weiner M, Mucida D
STAR Protoc
. 2022 Feb;
3(1):101157.
PMID: 35146454
The myenteric plexus is located between the longitudinal and circular layers of muscularis externa in the gastrointestinal tract. It contains a large network of enteric neurons that form the enteric...
2.
Ahrends T, Aydin B, Matheis F, Classon C, Marchildon F, Furtado G, et al.
Cell
. 2021 Oct;
184(23):5715-5727.e12.
PMID: 34717799
The enteric nervous system (ENS) controls several intestinal functions including motility and nutrient handling, which can be disrupted by infection-induced neuropathies or neuronal cell death. We investigated possible tolerance mechanisms...
3.
Kwesi-Maliepaard E, Aslam M, Alemdehy M, van den Brand T, McLean C, Vlaming H, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(34):20706-20716.
PMID: 32764145
Cytotoxic T cell differentiation is guided by epigenome adaptations, but how epigenetic mechanisms control lymphocyte development has not been well defined. Here we show that the histone methyltransferase DOT1L, which...
4.
Iglesias-Guimarais V, Ahrends T, de Vries E, Knobeloch K, Volkov A, Borst J
J Immunol
. 2020 Mar;
204(8):2110-2121.
PMID: 32169846
Type I IFN is produced upon infection and tissue damage and induces the expression of many IFN-stimulated genes (ISGs) that encode host-protective proteins. ISG15 is a ubiquitin-like molecule that can...
5.
Matheis F, Muller P, Graves C, Gabanyi I, Kerner Z, Costa-Borges D, et al.
Cell
. 2020 Jan;
180(1):64-78.e16.
PMID: 31923400
Enteric-associated neurons (EANs) are closely associated with immune cells and continuously monitor and modulate homeostatic intestinal functions, including motility and nutrient sensing. Bidirectional interactions between neuronal and immune cells are...
6.
Ahrends T, Busselaar J, Severson T, Babala N, de Vries E, Bovens A, et al.
Nat Commun
. 2019 Dec;
10(1):5531.
PMID: 31797935
CD4 T cell help is required for the generation of CD8 cytotoxic T lymphocyte (CTL) memory. Here, we use genome-wide analyses to show how CD4 T cell help delivered during...
7.
Borst J, Ahrends T, Babala N, Melief C, Kastenmuller W
Nat Rev Immunol
. 2018 Jul;
18(10):635-647.
PMID: 30057419
Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish efficient and durable antitumour...
8.
Babala N, Bovens A, de Vries E, Iglesias-Guimarais V, Ahrends T, Krummel M, et al.
Cancer Immunol Res
. 2018 May;
6(7):835-847.
PMID: 29764836
In a mouse model of therapeutic DNA vaccination, we studied how the subcellular localization of vaccine protein impacts antigen delivery to professional antigen-presenting cells and efficiency of CTL priming. Cytosolic,...
9.
Ahrends T, Borst J
Immunology
. 2018 Apr;
PMID: 29700809
Cancer immunotherapy focuses mainly on anti-tumour activity of CD8 cytotoxic T lymphocytes (CTLs). CTLs can directly kill all tumour cell types, provided they carry recognizable antigens. However, CD4 T cells...
10.
Ahrends T, Spanjaard A, Pilzecker B, Babala N, Bovens A, Xiao Y, et al.
Immunity
. 2017 Nov;
47(5):848-861.e5.
PMID: 29126798
CD4 T cells optimize the cytotoxic T cell (CTL) response in magnitude and quality, by unknown molecular mechanisms. We here present the transcriptomic changes in CTLs resulting from CD4 T ...