Tomas Aragon
Overview
Explore the profile of Tomas Aragon including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
1021
Followers
0
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Recent Articles
1.
Ortiz D, Peregrin N, Valencia M, Vinueza-Gavilanes R, Marin-Ordovas E, Ferrero R, et al.
Transl Neurodegener
. 2024 Sep;
13(1):49.
PMID: 39304897
No abstract available.
2.
Marlin E, Valencia M, Peregrin N, Ferrero R, Nicolas M, Vinueza-Gavilanes R, et al.
Br J Pharmacol
. 2023 Oct;
181(3):495-508.
PMID: 37823684
Background And Purpose: The integrated stress response (ISR) regulates translation in response to diverse stresses. ISR activation has been documented in amyotrophic lateral sclerosis (ALS) patients and ALS experimental models....
3.
Vinueza-Gavilanes R, Bravo-Gonzalez J, Basurco L, Boncristiani C, Fernandez-Irigoyen J, Santamaria E, et al.
Neurobiol Dis
. 2023 May;
183:106166.
PMID: 37245833
Synucleinopathies are a group of neurodegenerative diseases without effective treatment characterized by the abnormal aggregation of alpha-synuclein (aSyn) protein. Changes in levels or in the amino acid sequence of aSyn...
4.
Argemi J, Latasa M, Atkinson S, Blokhin I, Massey V, Gue J, et al.
Nat Commun
. 2023 Feb;
14(1):757.
PMID: 36765087
No abstract available.
5.
Marlin E, Viu-Idocin C, Arrasate M, Aragon T
Int J Mol Sci
. 2022 Jul;
23(14).
PMID: 35887167
In amyotrophic lateral sclerosis (ALS) patients, loss of cellular homeostasis within cortical and spinal cord motor neurons triggers the activation of the integrated stress response (ISR), an intracellular signaling pathway...
6.
Gomez-Puerta S, Ferrero R, Hochstoeger T, Zubiri I, Chao J, Aragon T, et al.
Elife
. 2022 Jun;
11.
PMID: 35730412
Endoplasmic reticulum (ER) to nucleus homeostatic signaling, known as the unfolded protein response (UPR), relies on the non-canonical splicing of XBP1 mRNA. The molecular switch that initiates splicing is the...
7.
Nistal-Villan E, Argemi J, De Jaime-Soguero A, Ferrero R, di Scala M, Rodriguez-Garcia E, et al.
Hum Gene Ther
. 2020 Nov;
32(7-8):341-348.
PMID: 33213214
Tight control of transgene expression is key to ensure the efficacy of a wide range of gene therapy interventions, in which the magnitude and duration of gene expression have to...
8.
Lasa M, Neri L, Carte B, Gazquez C, Aragon T, Aldabe R
J Mol Biol
. 2020 Sep;
432(22):5889-5901.
PMID: 32976911
Protein lifespan is regulated by co-translational modification by several enzymes, including methionine aminopeptidases and N-alpha-aminoterminal acetyltransferases. The NatB enzymatic complex is an N-terminal acetyltransferase constituted by two subunits, NAA20 and...
9.
Louie J, Scott H, DuBois A, Sturtz N, Lu W, Stoltey J, et al.
Clin Infect Dis
. 2020 Jul;
72(11):2018-2020.
PMID: 32687150
Coronavirus disease 2019 can cause significant mortality in the elderly in long-term care facilities (LTCF). We describe 4 LTCF outbreaks where mass testing identified a high proportion of asymptomatic infections...
10.
Bugallo R, Marlin E, Baltanas A, Toledo E, Ferrero R, Vinueza-Gavilanes R, et al.
Cell Death Dis
. 2020 May;
11(5):397.
PMID: 32457286
Loss of protein folding homeostasis features many of the most prevalent neurodegenerative disorders. As coping mechanism to folding stress within the endoplasmic reticulum (ER), the unfolded protein response (UPR) comprises...