Tom Maniatis
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Explore the profile of Tom Maniatis including associated specialties, affiliations and a list of published articles.
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94
Citations
15162
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Recent Articles
11.
Mathema B, Chen L, Chow K, Zhao Y, Zody M, Mediavilla J, et al.
Microbiol Spectr
. 2021 Nov;
9(3):e0188221.
PMID: 34787439
Emergence of SARS-CoV-2 with high transmission and immune evasion potential, the so-called variants of concern (VOC), is a major concern. We describe the early genomic epidemiology of SARS-CoV-2 recovered from...
12.
Chen L, Zody M, Di Germanio C, Martinelli R, Mediavilla J, Cunningham M, et al.
mSphere
. 2021 Aug;
6(4):e0048021.
PMID: 34431691
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs), harboring spike protein N-terminal domain (NTD) or receptor-binding domain (RBD) mutations, exhibit reduced susceptibility to convalescent-phase serum, commercial antibody...
13.
Harding O, Evans C, Ye J, Cheung J, Maniatis T, Holzbaur E
Proc Natl Acad Sci U S A
. 2021 Jun;
118(24).
PMID: 34099552
TANK-binding kinase 1 (TBK1) is a multifunctional kinase with an essential role in mitophagy, the selective clearance of damaged mitochondria. More than 90 distinct mutations in TBK1 are linked to...
14.
Lencz T, Yu J, Khan R, Flaherty E, Carmi S, Lam M, et al.
Neuron
. 2021 Mar;
109(9):1465-1478.e4.
PMID: 33756103
The identification of rare variants associated with schizophrenia has proven challenging due to genetic heterogeneity, which is reduced in founder populations. In samples from the Ashkenazi Jewish population, we report...
15.
Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, et al.
Science
. 2020 Sep;
370(6515).
PMID: 32972995
Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants...
16.
Flaherty E, Maniatis T
Curr Opin Genet Dev
. 2020 Jul;
65:144-150.
PMID: 32679536
During development, individual neurons extend highly branched arbors that innervate the surrounding territory, enabling the formation of appropriate synaptic connections. The clustered protocadherins (cPCDH), a family of diverse cell-surface homophilic...
17.
Leon W, Spatazza J, Rakela B, Chatterjee A, Pande V, Maniatis T, et al.
Elife
. 2020 Jul;
9.
PMID: 32633719
Cortical function critically depends on inhibitory/excitatory balance. Cortical inhibitory interneurons (cINs) are born in the ventral forebrain and migrate into cortex, where their numbers are adjusted by programmed cell death....
18.
Gerbino V, Kaunga E, Ye J, Canzio D, OKeeffe S, Rudnick N, et al.
Neuron
. 2020 Mar;
106(5):789-805.e5.
PMID: 32220666
DNA sequence variants in the TBK1 gene associate with or cause sporadic or familial amyotrophic lateral sclerosis (ALS). Here we show that mice bearing human ALS-associated TBK1 missense loss-of-function mutations,...
19.
Ye J, Cheung J, Gerbino V, Ahlsen G, Zimanyi C, Hirsh D, et al.
Proc Natl Acad Sci U S A
. 2019 Nov;
116(49):24517-24526.
PMID: 31748271
Exonic DNA sequence variants in the gene associate with both sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we examine functional defects in 25 missense TBK1 mutations, focusing on kinase...
20.
Canzio D, Maniatis T
Curr Opin Neurobiol
. 2019 Nov;
59:213-220.
PMID: 31710891
The assembly of functional neural circuits in vertebrate organisms requires complex mechanisms of self-recognition and self-avoidance. Neurites (axons and dendrites) from the same neuron recognize and avoid self, but engage...