Tom Ellis
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Explore the profile of Tom Ellis including associated specialties, affiliations and a list of published articles.
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87
Citations
2370
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Recent Articles
1.
Caro-Astorga J, Rogan M, Malci K, Ming H, Debenedictis E, James P, et al.
Trends Biotechnol
. 2025 Mar;
PMID: 40074634
Building DNA constructs of increasing complexity is key to synthetic biology. Golden Gate (GG) methods led to the creation of cloning toolkits - collections of modular standardized DNA parts hosted...
2.
Koeppel J, Ferreira R, Vanderstichele T, Riedmayr L, Peets E, Girling G, et al.
Science
. 2025 Jan;
387(6733):eado3979.
PMID: 39883775
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to...
3.
Malci K, Li I, Kisseroudis N, Ellis T
ACS Synth Biol
. 2024 Nov;
13(12):3857-3875.
PMID: 39509658
The fusion of synthetic biology and materials science offers exciting opportunities to produce sustainable materials that can perform programmed biological functions such as sensing and responding or enhance material properties...
4.
Heggie A, Thurston T, Ellis T
Trends Biotechnol
. 2024 Aug;
43(1):145-161.
PMID: 39117490
The demand for diverse nucleic acid delivery vectors, driven by recent biotechnological breakthroughs, offers opportunities for continuous improvements in efficiency, safety, and delivery capacity. With their enhanced safety and substantial...
5.
Walker K, Li I, Keane J, Goosens V, Song W, Lee K, et al.
Nat Biotechnol
. 2024 Apr;
PMID: 38565971
Environmental concerns are driving interest in postpetroleum synthetic textiles produced from microbial and fungal sources. Bacterial cellulose (BC) is a promising sustainable leather alternative, on account of its material properties,...
6.
Montenegro-Silva P, Ellis T, Dourado F, Gama M, Domingues L
Biotechnol Biofuels Bioprod
. 2024 Feb;
17(1):35.
PMID: 38424558
Background: Bacterial cellulose (BC) is a biocompatible material with unique mechanical properties, thus holding a significant industrial potential. Despite many acetic acid bacteria (AAB) being BC overproducers, cost-effective production remains...
7.
Blount B, Lu X, Driessen M, Jovicevic D, Sanchez M, Ciurkot K, et al.
Cell Genom
. 2023 Nov;
3(11):100418.
PMID: 38020971
We describe construction of the synthetic yeast chromosome XI () and reveal the effects of redesign at non-coding DNA elements. The 660-kb synthetic yeast genome project (Sc2.0) chromosome was assembled...
8.
Schindler D, Walker R, Jiang S, Brooks A, Wang Y, Muller C, et al.
Cell
. 2023 Nov;
186(24):5237-5253.e22.
PMID: 37944512
Here, we report the design, construction, and characterization of a tRNA neochromosome, a designer chromosome that functions as an additional, de novo counterpart to the native complement of Saccharomyces cerevisiae....
9.
Shaw W, Khalil A, Ellis T
ACS Synth Biol
. 2023 Nov;
12(11):3393-3405.
PMID: 37930278
Synthetic biology toolkits are one of the core foundations on which the field has been built, facilitating and accelerating efforts to reprogram cells and organisms for diverse biotechnological applications. The...
10.
Peng H, Chen R, Shaw W, Hapeta P, Jiang W, Bell D, et al.
ACS Synth Biol
. 2023 May;
12(6):1739-1749.
PMID: 37218844
Microbial-derived aromatics provide a sustainable and renewable alternative to petroleum-derived chemicals. In this study, we used the model yeast to produce aromatic molecules by exploiting the concept of modularity in...