Tom Dendooven
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Explore the profile of Tom Dendooven including associated specialties, affiliations and a list of published articles.
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20
Citations
302
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Recent Articles
1.
Lewis W, Paris G, Beedessee G, Koreny L, Flores V, Dendooven T, et al.
Curr Biol
. 2024 Nov;
34(23):5494-5506.e3.
PMID: 39571577
The plastids of photosynthetic organisms on land are predominantly "primary plastids," derived from an ancient endosymbiosis of a cyanobacterium. Conversely, the plastids of marine photosynthetic organisms were mostly gained through...
2.
Schwab J, Kimanius D, Burt A, Dendooven T, Scheres S
Nat Methods
. 2024 Aug;
21(10):1855-1862.
PMID: 39123079
How to deal with continuously flexing molecules is one of the biggest outstanding challenges in single-particle analysis of proteins from cryogenic-electron microscopy (cryo-EM) images. Here, we present DynaMight, a software...
3.
Dendooven T, Yatskevich S, Burt A, Chen Z, Bellini D, Rappsilber J, et al.
Nat Struct Mol Biol
. 2024 Apr;
31(7):1134-1144.
PMID: 38609662
Microtubule (MT) filaments, composed of α/β-tubulin dimers, are fundamental to cellular architecture, function and organismal development. They are nucleated from MT organizing centers by the evolutionarily conserved γ-tubulin ring complex...
4.
Muir K, Batters C, Dendooven T, Yang J, Zhang Z, Burt A, et al.
Science
. 2023 Dec;
382(6675):1184-1190.
PMID: 38060647
Kinetochores couple chromosomes to the mitotic spindle to segregate the genome during cell division. An error correction mechanism drives the turnover of kinetochore-microtubule attachments until biorientation is achieved. The structural...
5.
Dendooven T, Zhang Z, Yang J, McLaughlin S, Schwab J, Scheres S, et al.
Sci Adv
. 2023 Jul;
9(30):eadg7480.
PMID: 37506202
The point centromere of budding yeast specifies assembly of the large kinetochore complex to mediate chromatid segregation. Kinetochores comprise the centromere-associated inner kinetochore (CCAN) complex and the microtubule-binding outer kinetochore...
6.
Dendooven T, Sonnleitner E, Blasi U, Luisi B
EMBO J
. 2022 Dec;
42(3):e111129.
PMID: 36504222
The widely occurring bacterial RNA chaperone Hfq is a key factor in the post-transcriptional control of hundreds of genes in Pseudomonas aeruginosa. How this broadly acting protein can contribute to...
7.
Katsuya-Gaviria K, Paris G, Dendooven T, Bandyra K
RNA Biol
. 2022 Apr;
19(1):419-436.
PMID: 35438047
In all domains of life, RNA chaperones safeguard and guide the fate of the cellular RNA pool. RNA chaperones comprise structurally diverse proteins that ensure proper folding, stability, and ribonuclease...
8.
Yatskevich S, Muir K, Bellini D, Zhang Z, Yang J, Tischer T, et al.
Science
. 2022 Apr;
376(6595):844-852.
PMID: 35420891
Kinetochores assemble onto specialized centromeric CENP-A (centromere protein A) nucleosomes (CENP-A) to mediate attachments between chromosomes and the mitotic spindle. We describe cryo-electron microscopy structures of the human inner kinetochore...
9.
Burt A, Gaifas L, Dendooven T, Gutsche I
PLoS Biol
. 2021 Aug;
19(8):e3001319.
PMID: 34437530
Cryo-electron tomography (cryo-ET) and subtomogram averaging (STA) are increasingly used for macromolecular structure determination in situ. Here, we introduce a set of computational tools and resources designed to enable flexible...
10.
Dendooven T, Paris G, Shkumatov A, Islam M, Burt A, Kubanska M, et al.
Mol Microbiol
. 2021 Aug;
117(1):102-120.
PMID: 34415624
In organisms from all domains of life, multi-enzyme assemblies play central roles in defining transcript lifetimes and facilitating RNA-mediated regulation of gene expression. An assembly dedicated to such roles, known...