Tom C Hobman
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Explore the profile of Tom C Hobman including associated specialties, affiliations and a list of published articles.
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Articles
77
Citations
2039
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Recent Articles
1.
Rezaei R, Boulton S, Ahmadi M, Petryk J, Da Silva M, Kooshki Zamani N, et al.
Nat Biomed Eng
. 2024 Nov;
PMID: 39609558
Optimization of oncolytic viruses for therapeutic applications requires the strategic removal or mutagenesis of virulence genes alongside the insertion of transgenes that enhance viral replication, spread and immunogenicity. However, the...
2.
Snyman J, Villeneuve C, Snyman L, Martinez V, Dusfour I, Lecomte N, et al.
J Med Virol
. 2024 Nov;
96(11):e70064.
PMID: 39531228
No abstract available.
3.
McClelland R, Lin Y, Culp T, Noyce R, Evans D, Hobman T, et al.
Front Microbiol
. 2024 Jan;
14:1289387.
PMID: 38188566
Introduction: The COVID-19 pandemic was caused by the zoonotic betacoronavirus SARS-CoV-2. SARS-CoV-2 variants have emerged due to adaptation in humans, shifting SARS-CoV-2 towards an endemic seasonal virus. We have termed...
4.
Chen J, Abou Farraj R, Limonta D, Tabatabaei Dakhili S, Kerek E, Bhattacharya A, et al.
J Biol Chem
. 2023 Oct;
299(11):105341.
PMID: 37832873
The emergence of severe acute respiratory syndrome coronavirus 2, the causative agent of coronavirus disease 2019, has resulted in the largest pandemic in recent history. Current therapeutic strategies to mitigate...
5.
Lodge R, Xu Z, Eklund M, Sturzel C, Kirchhoff F, Tremblay M, et al.
mBio
. 2023 Sep;
14(5):e0195023.
PMID: 37773002
In order to efficiently produce infectious viral particles, HIV must counter several restrictions exerted by host cell antiviral proteins. MARCH1 is a member of the MARCH protein family that restricts...
6.
Bui D, Favell J, Kitova E, Li Z, McCord K, Schmidt E, et al.
ACS Cent Sci
. 2023 Jul;
9(7):1374-1387.
PMID: 37521792
Native mass spectrometry (nMS) screening of natural glycan libraries against glycan-binding proteins (GBPs) is a powerful tool for ligand discovery. However, as the glycan concentrations are unknown, affinities cannot be...
7.
Lopez-Orozco J, Fayad N, Khan J, Felix-Lopez A, Elaish M, Rohamare M, et al.
J Mol Biol
. 2023 Jun;
435(16):168170.
PMID: 37271493
Argonaute 2 (Ago2) is a key component of the RNA interference (RNAi) pathway, a gene-regulatory system that is present in most eukaryotes. Ago2 uses microRNAs (miRNAs) and small interfering RNAs...
8.
Luo S, Moussa E, Lopez-Orozco J, Felix-Lopez A, Ishida R, Fayad N, et al.
ACS Infect Dis
. 2023 Apr;
9(4):749-761.
PMID: 37011043
The recent emergence of SARS-CoV-2 in the human population has caused a global pandemic. The virus encodes two proteases, M and PL, that are thought to play key roles in...
9.
Gerla L, Moitra S, Pink D, Govindasamy N, Duchesne M, Reklow E, et al.
Viruses
. 2023 Feb;
15(2).
PMID: 36851770
Thymic stromal lymphopoietin (TSLP) is an epithelium-derived pro-inflammatory cytokine involved in lung inflammatory responses. Previous studies show conflicting observations in blood TSLP in COVID-19, while none report SARS-CoV-2 inducing TSLP...
10.
Girgis S, Xu Z, Oikonomopoulos S, Fedorova A, Tchesnokov E, Gordon C, et al.
Commun Biol
. 2022 Oct;
5(1):1140.
PMID: 36302891
Defective interfering (DI) particles arise during virus propagation, are conditional on parental virus for replication and packaging, and interfere with viral expansion. There is much interest in developing DIs as...