Todd W Ridky
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Explore the profile of Todd W Ridky including associated specialties, affiliations and a list of published articles.
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39
Citations
1816
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Recent Articles
1.
Natale C, Mercado S, Zhuang R, Aguirre-Portoles C, Olayide I, Arnatt C, et al.
Cancer Res Commun
. 2025 Mar;
PMID: 40066851
Estrogen effects in tissue are mediated in part through activation of the surface estrogen receptor GPER, a broadly expressed G protein-coupled receptor that impacts a wide range of normal and...
2.
Natale C, Mercado S, Zhuang R, Aguirre-Portoles C, Olayide I, Arnatt C, et al.
bioRxiv
. 2024 Dec;
PMID: 39651267
Estrogen effects in tissue are mediated in part through activation of the surface estrogen receptor GPER, a broadly expressed G protein-coupled receptor that impacts a wide range of normal and...
3.
Lee I, Doepner M, Weissenrieder J, Majer A, Mercado S, Estell A, et al.
Cancer Res Commun
. 2023 Aug;
3(8):1594-1606.
PMID: 37599786
Significance: Previous work demonstrated that LNS8801 inhibits cancer via GPER activation, especially in solid tumors. Here we show that LNS8801 inhibits AML via GPER-independent mechanisms that include ROS induction and...
4.
Natale C, Seykora J, Ridky T
bioRxiv
. 2023 Mar;
PMID: 36945570
GPER (G protein-coupled estrogen receptor) has been reported to play roles in several areas of physiology including cancer, metabolic disorders, and cardiovascular disease. However, the understanding of where this receptor...
5.
Hatterschide J, Natale C, Ridky T, White E
STAR Protoc
. 2023 Feb;
4(1):102101.
PMID: 36853703
Here, we provide a protocol to model the effects of changes to a small number of cells, such as those arising from a mutation or a virus infection, in stratified...
6.
Kohli J, Ge C, Fitsiou E, Doepner M, Brandenburg S, Faller W, et al.
Nat Commun
. 2022 Dec;
13(1):7923.
PMID: 36564381
Human melanocytic nevi (moles) result from a brief period of clonal expansion of melanocytes. As a cellular defensive mechanism against oncogene-induced hyperplasia, nevus-resident melanocytes enter a senescent state of stable...
7.
Doepner M, Lee I, Natale C, Brathwaite R, Venkat S, Kim S, et al.
Sci Adv
. 2022 Sep;
8(35):eabn4007.
PMID: 36054350
Melanoma risk is 30 times higher in people with lightly pigmented skin versus darkly pigmented skin. Using primary human melanocytes representing the full human skin pigment continuum and preclinical melanoma...
8.
Aguirre-Portoles C, Payne R, Trautz A, Foskett J, Natale C, Seykora J, et al.
Cancer Res
. 2021 Oct;
81(23):5991-6003.
PMID: 34706862
Melanoma and most other cancers occur more frequently and have worse prognosis in males compared with females. Although sex steroids are thought to be involved, classical androgen and estrogen receptors...
9.
Doepner M, Lee I, Ridky T
J Invest Dermatol
. 2020 Oct;
140(11):2114-2116.
PMID: 33099398
NRAS-driven melanomas frequently develop resistance to MAPK/extracellular signal-regulated kinase kinase inhibitors (MEKis), which limits their therapeutic utility. Nguyen et al. (2020) show that MEKi-resistant cells upregulate phosphoglycerate dehydrogenase (PHGDH), the...
10.
Natale C, Li J, Pitarresi J, Norgard R, Dentchev T, Capell B, et al.
Cell Mol Gastroenterol Hepatol
. 2020 May;
10(4):868-880.e1.
PMID: 32376419
Background & Aims: Female sex is associated with lower incidence and improved clinical outcomes for most cancer types including pancreatic ductal adenocarcinoma (PDAC). The mechanistic basis for this sex difference...