Todd J Herron
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Explore the profile of Todd J Herron including associated specialties, affiliations and a list of published articles.
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49
Citations
2328
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Recent Articles
1.
Herron T, Devaney E, Guerrero-Serna G, Mundada L, Metzger J
bioRxiv
. 2024 Aug;
PMID: 39211095
The R403Q mutation of human cardiac β-myosin heavy chain was the first missense mutation of a sarcomeric protein identified as being causal for hypertrophic cardiomyopathy (HCM), in humans. The direct...
2.
Ponce-Balbuena D, Tyrrell D, Cruz-Cortes C, Guerrero-Serna G, Monteiro da Rocha A, Herron T, et al.
bioRxiv
. 2024 Aug;
PMID: 39149279
Obesity is a major risk factor for atrial fibrillation (AF) the most common serious cardiac arrhythmia, but the molecular mechanisms underlying diet-induced AF remain unclear. In this study, we subjected...
3.
Dow R, DeLong C, Jiang G, Attili D, Creech J, Kraan R, et al.
Biol Psychiatry Glob Open Sci
. 2024 Apr;
4(3):100296.
PMID: 38560725
A common genetic risk factor for bipolar disorder is , a gene that is also critical for cardiac rhythm. The impact of mutations on bipolar patient cardiac rhythm is unknown....
4.
Allan A, Creech J, Hausner C, Krajcarski P, Gunawan B, Poulin N, et al.
iScience
. 2023 Jul;
26(7):107142.
PMID: 37416454
hiPSC-CMs are being considered by the Food and Drug Administration and other regulatory agencies for cardiotoxicity screening to provide human-relevant safety data. Widespread adoption of hiPSC-CMs in regulatory and academic...
5.
Monteiro da Rocha A, Allan A, Block T, Creech J, Herron T
J Vis Exp
. 2023 Apr;
(193).
PMID: 37036202
Human induced stem cell-derived cardiomyocytes (hiPSC-CMs) are used to replace and reduce the dependence on animals and animal cells for preclinical cardiotoxicity testing. In two-dimensional monolayer formats, hiPSC-CMs recapitulate the...
6.
Lozhkin A, Vendrov A, Ramos-Mondragon R, Canugovi C, Stevenson M, Herron T, et al.
Redox Biol
. 2022 Oct;
57:102474.
PMID: 36183542
Diastolic dysfunction (DD) underlies heart failure with preserved ejection fraction (HFpEF), a clinical syndrome associated with aging that is becoming more prevalent. Despite extensive clinical studies, no effective treatment exists...
7.
Jimenez-Vazquez E, Arad M, Macias A, Vera-Pedrosa M, Cruz F, Gutierrez L, et al.
Elife
. 2022 Jun;
11.
PMID: 35762211
Background: Patients with cardiomyopathy of Duchenne Muscular Dystrophy (DMD) are at risk of developing life-threatening arrhythmias, but the mechanisms are unknown. We aimed to determine the role of ion channels...
8.
Aguayo-Ortiz R, Creech J, Jimenez-Vazquez E, Guerrero-Serna G, Wang N, Monteiro da Rocha A, et al.
Sci Rep
. 2021 Aug;
11(1):16580.
PMID: 34400719
Membrane proteins constitute a substantial fraction of the human proteome, thus representing a vast source of therapeutic drug targets. Indeed, newly devised technologies now allow targeting "undruggable" regions of membrane...
9.
Davis J, Chouman A, Creech J, Monteiro da Rocha A, Ponce-Balbuena D, Jimenez Vazquez E, et al.
JCI Insight
. 2021 Apr;
6(10).
PMID: 33878037
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been used extensively to model inherited heart diseases, but hiPSC-CM models of ischemic heart disease are lacking. Here, our objective was to...
10.
Block T, Creech J, Monteiro da Rocha A, Marinkovic M, Ponce-Balbuena D, Jimenez-Vazquez E, et al.
Sci Rep
. 2020 Nov;
10(1):19071.
PMID: 33149250
The immature phenotype of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) is a major limitation to the use of these valuable cells for pre-clinical toxicity testing and for disease...