Guadalupe Guerrero-Serna
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Explore the profile of Guadalupe Guerrero-Serna including associated specialties, affiliations and a list of published articles.
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42
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1244
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Recent Articles
1.
Herron T, Devaney E, Guerrero-Serna G, Mundada L, Metzger J
bioRxiv
. 2024 Aug;
PMID: 39211095
The R403Q mutation of human cardiac β-myosin heavy chain was the first missense mutation of a sarcomeric protein identified as being causal for hypertrophic cardiomyopathy (HCM), in humans. The direct...
2.
Romero-Becerra R, Cruz F, Mora A, Lopez J, Ponce-Balbuena D, Allan A, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(12):1204-1220.
PMID: 39196141
Ventricular fibrillation (VF) is a leading immediate cause of sudden cardiac death. There is a strong association between aging and VF, although the mechanisms are unclear, limiting the availability of...
3.
Ponce-Balbuena D, Tyrrell D, Cruz-Cortes C, Guerrero-Serna G, Monteiro da Rocha A, Herron T, et al.
bioRxiv
. 2024 Aug;
PMID: 39149279
Obesity is a major risk factor for atrial fibrillation (AF) the most common serious cardiac arrhythmia, but the molecular mechanisms underlying diet-induced AF remain unclear. In this study, we subjected...
4.
Seflova J, Cruz-Cortes C, Guerrero-Serna G, Robia S, Espinoza-Fonseca L
PNAS Nexus
. 2024 Jan;
3(1):pgad453.
PMID: 38222469
The discovery of allosteric modulators is an emerging paradigm in drug discovery, and signal transduction is a subtle and dynamic process that is challenging to characterize. We developed a time-correlated...
5.
Rathod N, Guerrero-Serna G, Young H, Espinoza-Fonseca L
Biochim Biophys Acta Mol Cell Res
. 2023 Nov;
1871(1):119613.
PMID: 37918638
Myoregulin (MLN) is a protein that regulates the activity of the sarcoplasmic reticulum Ca-ATPase (SERCA) without affecting its affinity for Ca. MLN's residue Lys27 is located at a site where...
6.
Cruz-Cortes C, Velasco-Saavedra M, Fernandez-de Gortari E, Guerrero-Serna G, Aguayo-Ortiz R, Espinoza-Fonseca L
J Biol Chem
. 2023 Apr;
299(5):104681.
PMID: 37030504
We report a novel small-molecule screening approach that combines data augmentation and machine learning to identify Food and Drug Administration (FDA)-approved drugs interacting with the calcium pump (Sarcoplasmic reticulum Ca-ATPase,...
7.
Liu A, Rathod N, Guerrero-Serna G, Young H, Espinoza-Fonseca L
Biochemistry
. 2023 Apr;
62(8):1331-1336.
PMID: 37014032
Myoregulin (MLN) is a member of the regulin family, a group of homologous membrane proteins that bind to and regulate the activity of the sarcoplasmic reticulum Ca-ATPase (SERCA). MLN, which...
8.
Jimenez-Vazquez E, Arad M, Macias A, Vera-Pedrosa M, Cruz F, Gutierrez L, et al.
Elife
. 2022 Jun;
11.
PMID: 35762211
Background: Patients with cardiomyopathy of Duchenne Muscular Dystrophy (DMD) are at risk of developing life-threatening arrhythmias, but the mechanisms are unknown. We aimed to determine the role of ion channels...
9.
Liu A, Aguayo-Ortiz R, Guerrero-Serna G, Wang N, Blin M, Goldstein D, et al.
Comput Struct Biotechnol J
. 2022 Jan;
20:380-384.
PMID: 35035790
Phospholamban (PLN) and Sarcolipin (SLN) are homologous membrane proteins that belong to the family of proteins that regulate the activity of the cardiac calcium pump (sarcoplasmic reticulum Ca-ATPase, SERCA). PLN...
10.
Aguayo-Ortiz R, Creech J, Jimenez-Vazquez E, Guerrero-Serna G, Wang N, Monteiro da Rocha A, et al.
Sci Rep
. 2021 Aug;
11(1):16580.
PMID: 34400719
Membrane proteins constitute a substantial fraction of the human proteome, thus representing a vast source of therapeutic drug targets. Indeed, newly devised technologies now allow targeting "undruggable" regions of membrane...