Todd Druley
Overview
Explore the profile of Todd Druley including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
950
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0
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Recent Articles
1.
Berko E, Naranjo A, Daniels A, McNulty S, Krytska K, Druley T, et al.
J Clin Oncol
. 2025 Mar;
:JCO2402407.
PMID: 40036726
Purpose: Relapsed high-risk neuroblastomas (NBLs) are enriched for targetable mutations in and RAS-MAPK pathways, yet the prognostic effect of these aberrations and relevance of subclonal mutations at diagnosis remain undefined....
2.
Jensen J, Bobek O, Chan I, Miller B, Hillman D, Heller G, et al.
Clin Cancer Res
. 2024 Sep;
30(21):4910-4919.
PMID: 39287426
Purpose: Mutations in hematopoietic progenitor cells accumulate with age leading to clonal expansion, termed clonal hematopoiesis (CH). CH in the general population is associated with hematopoietic neoplasms and reduced overall...
3.
Cai S, Huang Y, Lance J, Mao H, Dunbar A, McNulty S, et al.
Blood Adv
. 2023 Oct;
8(2):429-440.
PMID: 37871309
Enasidenib (ENA) is an inhibitor of isocitrate dehydrogenase 2 (IDH2) approved for the treatment of patients with IDH2-mutant relapsed/refractory acute myeloid leukemia (AML). In this phase 2/1b Beat AML substudy,...
4.
Walsh K, Raghavachari N, Kerr C, Bick A, Cummings S, Druley T, et al.
Front Aging
. 2022 Jul;
3:841796.
PMID: 35821803
Aging is characterized by increased mortality, functional decline, and exponential increases in the incidence of diseases such as cancer, stroke, cardiovascular disease, neurological disease, respiratory disease, etc. Though the role...
5.
Hitzler J, Alonzo T, Gerbing R, Beckman A, Hirsch B, Raimondi S, et al.
Blood
. 2021 Jul;
138(23):2337-2346.
PMID: 34320162
Myeloid leukemia in children with Down syndrome (ML-DS) is associated with young age and somatic GATA1 mutations. Because of high event-free survival (EFS) and hypersensitivity of the leukemic blasts to...
6.
Erez N, Israitel L, Bitman-Lotan E, Wong W, Raz G, Cornelio-Parra D, et al.
Elife
. 2021 Feb;
10.
PMID: 33629655
A hallmark of aging is loss of differentiated cell identity. Aged midgut differentiated enterocytes (ECs) lose their identity, impairing tissue homeostasis. To discover identity regulators, we performed an RNAi screen...
7.
Bolton K, Ptashkin R, Gao T, Braunstein L, Devlin S, Kelly D, et al.
Nat Genet
. 2020 Oct;
52(11):1219-1226.
PMID: 33106634
Acquired mutations are pervasive across normal tissues. However, understanding of the processes that drive transformation of certain clones to cancer is limited. Here we study this phenomenon in the context...
8.
Rajan V, Melong N, Wong W, King B, Tong S, Mahajan N, et al.
Haematologica
. 2020 Oct;
105(10):2391-2399.
PMID: 33054079
Xenograft models are invaluable tools in establishing the current paradigms of hematopoiesis and leukemogenesis. The zebrafish has emerged as a robust alternative xenograft model but, like mice, lack specific cytokines...
9.
Carlson P, Wojczynski M, Druley T, Lee J, Zmuda J, Thyagarajan B
BMC Med Genomics
. 2020 Apr;
13(1):61.
PMID: 32272925
Background: Phenotypic expression of pathogenic variants in individuals with no family history of inherited disorders remains unclear. Methods: We evaluated the prevalence of pathogenic variants in 25 genes associated with...
10.
Camet M, Hayashi S, Druley T, Henry J, Gettinger K, Stacy A, et al.
Am J Med Genet A
. 2019 Jul;
179(11):2307-2310.
PMID: 31339626
No abstract available.