Tobin E Brown
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Explore the profile of Tobin E Brown including associated specialties, affiliations and a list of published articles.
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14
Citations
569
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0
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Recent Articles
1.
Gunay K, Chang T, Skillin N, Rao V, Macdougall L, Cutler A, et al.
Nat Mater
. 2023 May;
22(6):777-785.
PMID: 37217701
Hydrogels are extensively used as tunable, biomimetic three-dimensional cell culture matrices, but optically deep, high-resolution images are often difficult to obtain, limiting nanoscale quantification of cell-matrix interactions and outside-in signalling....
2.
Higgins C, Brown T, Killgore J
Addit Manuf
. 2021 Jul;
38.
PMID: 34268068
Stereolithography (SLA) and digital light processing (DLP) are powerful additive manufacturing techniques that address a wide range of applications including regenerative medicine, prototyping, and manufacturing. Unfortunately, these printing processes introduce...
3.
Silver J, Gunay K, Cutler A, Vogler T, Brown T, Pawlikowski B, et al.
Sci Adv
. 2021 Mar;
7(11).
PMID: 33712460
The skeletal muscle microenvironment transiently remodels and stiffens after exercise and injury, as muscle ages, and in myopathic muscle; however, how these changes in stiffness affect resident muscle stem cells...
4.
Ceccato T, Starbuck R, Hall J, Walker C, Brown T, Killgore J, et al.
J Am Heart Assoc
. 2020 Sep;
9(19):e017025.
PMID: 32924724
Background Cardiac fibroblasts (CFs) have the ability to sense stiffness changes and respond to biochemical cues to modulate their states as either quiescent or activated myofibroblasts. Given the potential for...
5.
Yavitt F, Brown T, Hushka E, Brown M, Gjorevski N, Dempsey P, et al.
Adv Mater
. 2020 Jun;
32(30):e1905366.
PMID: 32548863
Intestinal organoids are useful in vitro models for basic and translational studies aimed at understanding and treating disease. However, their routine culture relies on animal-derived matrices that limit translation to...
6.
Hushka E, Yavitt F, Brown T, Dempsey P, Anseth K
Adv Healthc Mater
. 2020 Jan;
9(8):e1901214.
PMID: 31957249
Intestinal organoid protocols rely on the use of extracellular scaffolds, typically Matrigel, and upon switching from growth to differentiation promoting media, a symmetry breaking event takes place. During this stage,...
7.
Killaars A, Grim J, Walker C, Hushka E, Brown T, Anseth K
Adv Sci (Weinh)
. 2019 Feb;
6(3):1801483.
PMID: 30775233
Bone marrow derived human mesenchymal stem cells (hMSCs) are a promising cell source for regenerative therapies; however, ex vivo expansion is often required to achieve clinically useful cells numbers. Recent...
8.
Brown T, Silver J, Worrell B, Marozas I, Yavitt F, Gunay K, et al.
J Am Chem Soc
. 2018 Sep;
140(37):11585-11588.
PMID: 30183266
Muscle cells sense the mechanical properties of their microenvironment, and these properties can change in response to injury or disease. Hydrogels with dynamic material properties can be used to study...
9.
Grim J, Brown T, Aguado B, Chapnick D, Viert A, Liu X, et al.
ACS Cent Sci
. 2018 Aug;
4(7):909-916.
PMID: 30062120
Biomolecule-functionalized hydrogels have emerged as valuable cell culture platforms to recapitulate the mechanical and biochemical properties of the extracellular niche. The typical strategy to functionalize hydrogels with biomolecules involves directly...
10.
Brown T, Carberry B, Worrell B, Dudaryeva O, McBride M, Bowman C, et al.
Biomaterials
. 2018 Apr;
178:496-503.
PMID: 29653871
The extracellular matrix (ECM) constitutes a viscoelastic environment for cells. A growing body of evidence suggests that the behavior of cells cultured in naturally-derived or synthetic ECM mimics is influenced...