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Tobias Wiestler

Explore the profile of Tobias Wiestler including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 695
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Recent Articles
1.
Sadnicka A, Wiestler T, Butler K, Altenmuller E, Edwards M, Ejaz N, et al.
Sci Rep . 2024 Jul; 14(1):15972. PMID: 38987302
Task-specific dystonia leads to loss of sensorimotor control for a particular motor skill. Although focal in nature, it is hugely disabling and can terminate professional careers in musicians. Biomarkers for...
2.
Sadnicka A, Wiestler T, Butler K, Altenmuller E, Edwards M, Ejaz N, et al.
Brain . 2022 Sep; 146(4):1511-1522. PMID: 36170332
Musician's dystonia presents with a persistent deterioration of motor control during musical performance. A predominant hypothesis has been that this is underpinned by maladaptive neural changes to the somatotopic organization...
3.
Kapil A, Meier A, Steele K, Rebelatto M, Nekolla K, Haragan A, et al.
IEEE Trans Med Imaging . 2021 May; 40(9):2513-2523. PMID: 34003747
We report the ability of two deep learning-based decision systems to stratify non-small cell lung cancer (NSCLC) patients treated with checkpoint inhibitor therapy into two distinct survival groups. Both systems...
4.
Widmaier M, Wiestler T, Walker J, Barker C, Scott M, Sekhavati F, et al.
Mod Pathol . 2019 Sep; 33(3):380-390. PMID: 31527709
Tumor programmed cell death ligand-1 (PD-L1) expression is a key biomarker to identify patients with non-small cell lung cancer who may have an enhanced response to anti-programmed cell death-1 (PD-1)/PD-L1...
5.
Althammer S, Tan T, Spitzmuller A, Rognoni L, Wiestler T, Herz T, et al.
J Immunother Cancer . 2019 May; 7(1):121. PMID: 31060602
Background: Immune checkpoint therapies (ICTs) targeting the programmed cell death-1 (PD1)/programmed cell death ligand-1 (PD-L1) pathway have improved outcomes for patients with non-small cell lung cancer (NSCLC), particularly those with...
6.
Steele K, Tan T, Korn R, DaCosta K, Brown C, Kuziora M, et al.
J Immunother Cancer . 2018 Mar; 6(1):20. PMID: 29510739
Background: Immuno-oncology and cancer immunotherapies are areas of intense research. The numbers and locations of CD8+ tumor-infiltrating lymphocytes (TILs) are important measures of the immune response to cancer with prognostic,...
7.
Waters S, Wiestler T, Diedrichsen J
J Neurosci . 2017 Jul; 37(31):7500-7512. PMID: 28674174
What is the role of ipsilateral motor and premotor areas in motor learning? One view is that ipsilateral activity suppresses contralateral motor cortex and, accordingly, that inhibiting ipsilateral regions can...
8.
Wiestler T, Waters-Metenier S, Diedrichsen J
J Neurosci . 2014 Apr; 34(14):5054-64. PMID: 24695723
Many daily activities rely on the ability to produce meaningful sequences of movements. Motor sequences can be learned in an effector-specific fashion (such that benefits of training are restricted to...
9.
Waters-Metenier S, Husain M, Wiestler T, Diedrichsen J
J Neurosci . 2014 Jan; 34(3):1037-50. PMID: 24431461
Complex manual tasks-everything from buttoning up a shirt to playing the piano-fundamentally involve two components: (1) generating specific patterns of muscle activity (here, termed "synergies"); and (2) stringing these into...
10.
Wiestler T, Diedrichsen J
Elife . 2013 Jul; 2:e00801. PMID: 23853714
Motor-skill learning can be accompanied by both increases and decreases in brain activity. Increases may indicate neural recruitment, while decreases may imply that a region became unimportant or developed a...