Tobias Sahr
Overview
Explore the profile of Tobias Sahr including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
794
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Recent Articles
1.
Malmsheimer S, Grin I, Bohn E, Franz-Wachtel M, Macek B, Sahr T, et al.
PLoS Pathog
. 2024 Nov;
20(11):e1012118.
PMID: 39546547
To promote intracellular survival and infection, Legionella spp. translocate hundreds of effector proteins into eukaryotic host cells using a type IV b protein secretion system (T4bSS). T4bSS are well known...
2.
Malmsheimer S, Grin I, Bohn E, Franz-Wachtel M, Macek B, Sahr T, et al.
bioRxiv
. 2024 Apr;
PMID: 38559167
To promote intracellular survival and infection, translocate hundreds of effector proteins into eukaryotic host cells using a type IV b protein secretion system (T4bSS). T4bSS are well known to translocate...
3.
Sharma R, Adams M, Griffith-Jones S, Sahr T, Gomez-Valero L, Weis F, et al.
Nat Commun
. 2023 Nov;
14(1):7068.
PMID: 37923743
Legionella pneumophila (LP) secretes more than 300 effectors into the host cytosol to facilitate intracellular replication. One of these effectors, SidH, 253 kDa in size with no sequence similarity to...
4.
Matthey-Doret C, Colp M, Escoll P, Thierry A, Moreau P, Curtis B, et al.
Genome Res
. 2022 Sep;
32(9):1698-1710.
PMID: 36109147
The unicellular amoeba is ubiquitous in aquatic environments, where it preys on bacteria. The organism also hosts bacterial endosymbionts, some of which are parasitic, including human pathogens such as and...
5.
Sahr T, Escoll P, Rusniok C, Bui S, Pehau-Arnaudet G, Lavieu G, et al.
Nat Commun
. 2022 Feb;
13(1):762.
PMID: 35140216
Legionella pneumophila is an intracellular bacterial pathogen that can cause a severe form of pneumonia in humans, a phenotype evolved through interactions with aquatic protozoa in the environment. Here, we...
6.
Escoll P, Platon L, Drame M, Sahr T, Schmidt S, Rusniok C, et al.
Elife
. 2021 Dec;
10.
PMID: 34882089
the causative agent of Legionnaires' disease, a severe pneumonia, injects via a type 4 secretion system (T4SS) more than 300 proteins into macrophages, its main host cell in humans. Certain...
7.
Hochstrasser R, Kessler A, Sahr T, Simon S, Schell U, Gomez-Valero L, et al.
Environ Microbiol
. 2019 Jan;
21(3):1035-1053.
PMID: 30623561
The causative agent of Legionnaires' disease, Legionella pneumophila, colonizes amoebae and biofilms in the environment. The opportunistic pathogen employs the Lqs (Legionella quorum sensing) system and the signalling molecule LAI-1...
8.
Oliva G, Sahr T, Buchrieser C
Front Cell Infect Microbiol
. 2018 Feb;
8:3.
PMID: 29404281
is a gram-negative bacterium that inhabits freshwater ecosystems, where it is present in biofilm or as planktonic form. is mainly found associated with protozoa, which serve as protection from hostile...
9.
Hauslein I, Sahr T, Escoll P, Klausner N, Eisenreich W, Buchrieser C
Open Biol
. 2017 Nov;
7(11).
PMID: 29093212
CsrA plays a crucial role in the life-stage-specific expression of virulence phenotypes and metabolic activity. However, its exact role is only partly known. To elucidate how CsrA impacts metabolism we...
10.
Sahr T, Rusniok C, Impens F, Oliva G, Sismeiro O, Coppee J, et al.
PLoS Genet
. 2017 Feb;
13(2):e1006629.
PMID: 28212376
The carbon storage regulator protein CsrA regulates cellular processes post-transcriptionally by binding to target-RNAs altering translation efficiency and/or their stability. Here we identified and analyzed the direct targets of CsrA...