Tobias Marquardt
Overview
Explore the profile of Tobias Marquardt including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
164
Followers
0
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Recent Articles
1.
Vakalopoulos A, Basting D, Brechmann M, Teller H, Boultadakis Arapinis M, Straub A, et al.
J Med Chem
. 2024 Oct;
67(21):19165-19187.
PMID: 39463278
Autonomic disbalance, i.e., sympathetic overactivation and parasympathetic withdrawal, is a causal driver of disease progression in heart failure. While sympatholytic drugs are established treatments, no drug therapy restoring vagal control...
2.
Becker-Pelster E, Hahn M, Delbeck M, Dietz L, Huser J, Kopf J, et al.
Respir Res
. 2022 Oct;
23(1):272.
PMID: 36183104
Background: Oxidative stress associated with severe cardiopulmonary diseases leads to impairment in the nitric oxide/soluble guanylate cyclase signaling pathway, shifting native soluble guanylate cyclase toward heme-free apo-soluble guanylate cyclase. Here...
3.
Valadez Huerta G, Flasbart V, Marquardt T, Radici P, Kabelac S
Entropy (Basel)
. 2020 Dec;
20(6).
PMID: 33265559
The calculation of the entropy production rate within an operational high temperature solid oxide fuel cell (SOFC) is necessary to design and improve heating and cooling strategies. However, due to...
4.
Zhao X, Wilmen A, Wang D, Wang X, Bauzon M, Kim J, et al.
Nat Commun
. 2020 Jun;
11(1):2992.
PMID: 32532974
Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective functions. Based on the hypothesis that specific inhibition of APC's anticoagulant but not its cytoprotective activity can...
5.
Schulze V, Klar U, Kosemund D, Wengner A, Siemeister G, Stockigt D, et al.
J Med Chem
. 2020 Apr;
63(15):8025-8042.
PMID: 32338514
Inhibition of monopolar spindle 1 (MPS1) kinase represents a novel approach to cancer treatment: instead of arresting the cell cycle in tumor cells, cells are driven into mitosis irrespective of...
6.
May M, Brohm D, Harrenga A, Marquardt T, Riedl B, Kreuter J, et al.
Antiviral Res
. 2012 May;
95(2):182-91.
PMID: 22580131
The RNA-dependent RNA polymerase NS5B of the hepatitis C virus (HCV) has emerged as one of the key targets for antiviral drug discovery. Here we describe a novel non-nucleoside inhibitor...
7.
Koller-Eichhorn R, Marquardt T, Gail R, Wittinghofer A, Kostrewa D, Kutay U, et al.
J Biol Chem
. 2007 Apr;
282(27):19928-37.
PMID: 17430889
Purine nucleotide-binding proteins build the large family of P-loop GTPases and related ATPases, which perform essential functions in all kingdoms of life. The Obg family comprises a group of ancient...
8.
Frese S, Schubert W, Findeis A, Marquardt T, Roske Y, Stradal T, et al.
J Biol Chem
. 2006 Apr;
281(26):18236-45.
PMID: 16636066
Nck proteins are essential Src homology (SH) 2 and SH3 domain-bearing adapters that modulate actin cytoskeleton dynamics by linking proline-rich effector molecules to tyrosine kinases or phosphorylated signaling intermediates. Two...
9.
Marquardt T, Kostrewa D, Balakrishnan R, Gasperina A, Kambach C, Podjarny A, et al.
J Mol Biol
. 2005 Oct;
354(2):304-16.
PMID: 16242712
Aldo-keto reductase AKR11C1 from Bacillus halodurans, a new member of aldo-keto reductase (AKR) family 11, has been characterized structurally and biochemically. The structures of the apo and NADPH bound form...