Tobias Brummer
Overview
Explore the profile of Tobias Brummer including associated specialties, affiliations and a list of published articles.
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10
Citations
145
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Recent Articles
1.
Fleischer V, Brummer T, Muthuraman M, Steffen F, Heldt M, Protopapa M, et al.
Front Immunol
. 2025 Feb;
16:1532660.
PMID: 39958357
Objective: Establishing biomarkers to predict multiple sclerosis (MS) disability accrual has been challenging using a single biomarker approach, likely due to the complex interplay of neuroinflammation and neurodegeneration. Here, we...
2.
Protopapa M, Steffen F, Schraad M, Ruck T, Ozturk M, Hanuscheck N, et al.
Ann Neurol
. 2024 Nov;
97(3):596-605.
PMID: 39588882
Objective: We examined the impact of the rs10191329 genetic risk variant on neuroaxonal damage as measured by serum neurofilament light chain (sNfL) levels, and disability progression in people with multiple...
3.
Winter Y, Simon O, Spreer A, Othman A, Altmann S, Brandt M, et al.
Int J Stroke
. 2024 Sep;
20(2):205-214.
PMID: 39295077
Background: Neuroborreliosis is a tick-borne condition that affects the central and/or peripheral nervous system. Cerebral infarction associated with neuroborreliosis-related vasculitis has been reported in only a handful of cases. Therefore,...
4.
Brummer T, Lotz J, Dresel C, Birklein F
Ther Adv Neurol Disord
. 2024 Feb;
17:17562864231224108.
PMID: 38414722
We present a case of a 42-year-old woman with paraneoplastic anti-N-Methyl-D-Aspartat (NMDA)-receptor encephalitis and concurrent neuroborreliosis that was initially misdiagnosed as post-COVID-19 syndrome. Clinically, the patient presented with a range...
5.
Brummer T, Schillner M, Steffen F, Kneilmann F, Wasser B, Uphaus T, et al.
J Neuroinflammation
. 2023 Nov;
20(1):262.
PMID: 37957728
Objective: Ongoing neuroaxonal damage is a major contributor to disease progression and long-term disability in multiple sclerosis. However, spatio-temporal distribution and pathophysiological mechanisms of neuroaxonal damage during acute relapses and...
6.
Brummer T, Muthuraman M, Steffen F, Uphaus T, Minch L, Person M, et al.
Brain Commun
. 2022 Jul;
4(4):fcac153.
PMID: 35813883
Disability in multiple sclerosis is generally classified by sensory and motor symptoms, yet cognitive impairment has been identified as a frequent manifestation already in the early disease stages. Imaging- and...
7.
Brummer T, Zipp F, Bittner S
Curr Opin Neurobiol
. 2022 Jun;
75:102588.
PMID: 35732103
Multiple sclerosis (MS) is a chronic autoimmune condition of the central nervous system (CNS) characterized by acute inflammatory relapses, chronic neuro-axonal degeneration, and subsequent disability progression. T cells - in...
8.
Brummer T, Ruck T, Meuth S, Zipp F, Bittner S
Ther Adv Neurol Disord
. 2021 Aug;
14:17562864211035542.
PMID: 34457039
The past decades have yielded major therapeutic advances in many autoimmune conditions - such as multiple sclerosis (MS) - and thus ushered in a new era of more targeted and...
9.
Hsia H, Tushaus J, Brummer T, Zheng Y, Scilabra S, Lichtenthaler S
Cell Mol Life Sci
. 2019 Jun;
76(16):3055-3081.
PMID: 31236626
'A disintegrin and metalloproteases' (ADAMs) are a family of transmembrane proteins with diverse functions in multicellular organisms. About half of the ADAMs are active metalloproteases and cleave numerous cell surface...
10.
Brummer T, Muller S, Pan-Montojo F, Yoshida F, Fellgiebel A, Tomita T, et al.
EMBO Mol Med
. 2019 Mar;
11(4).
PMID: 30833305
The metalloprotease ADAM10 is a drug target in Alzheimer's disease, where it cleaves the amyloid precursor protein (APP) and lowers amyloid-beta. Yet, ADAM10 has additional substrates, which may cause mechanism-based...