Ting-Xi Yu
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Explore the profile of Ting-Xi Yu including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
380
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0
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Recent Articles
1.
Sharma S, Xiao L, Chung H, Chen T, Mallard C, Warner B, et al.
Cell Mol Gastroenterol Hepatol
. 2024 Sep;
19(1):101410.
PMID: 39349247
Background & Aims: Small noncoding vault RNAs (vtRNAs) are involved in many cell processes important for health and disease, but their pathobiological functions in the intestinal epithelium are underexplored. Here,...
2.
Li R, Cairns C, Yu T, Jaladanki R, Dodson C, Chung H, et al.
Physiol Rep
. 2024 Sep;
12(17):e70021.
PMID: 39261977
Many pathological conditions lead to defects in intestinal epithelial integrity and loss of barrier function; Sphingosine-1-phosphate (S1P) has been shown to augment intestinal barrier integrity, though the exact mechanisms are...
3.
Kwon M, Chung H, Xiao L, Yu T, Sharma S, Cairns C, et al.
Am J Physiol Cell Physiol
. 2024 Aug;
327(3):C817-C829.
PMID: 39099425
Paneth cells at the bottom of small intestinal crypts secrete antimicrobial peptides, enzymes, and growth factors and contribute to pathogen clearance and maintenance of the stem cell niche. Loss of...
4.
Ma X, Xiao L, Wen S, Yu T, Sharma S, Chung H, et al.
EMBO Rep
. 2022 Nov;
24(2):e54925.
PMID: 36440604
Vault RNAs (vtRNAs) are small noncoding RNAs and highly expressed in many eukaryotes. Here, we identified vtRNA2-1 as a novel regulator of the intestinal barrier via interaction with RNA-binding protein...
5.
Yu T, Kalakonda S, Liu X, Han N, Chung H, Xiao L, et al.
JCI Insight
. 2022 Oct;
7(19).
PMID: 36214222
Intestinal epithelial integrity is commonly disrupted in patients with critical disorders, but the exact underlying mechanisms are unclear. Long noncoding RNAs transcribed from ultraconserved regions (T-UCRs) control different cell functions...
6.
Xiao L, Ma X, Luo J, Chung H, Kwon M, Yu T, et al.
Gastroenterology
. 2021 Jun;
161(4):1303-1317.e3.
PMID: 34116030
Background & Aims: Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs that form covalently closed circles. Although circRNAs influence many biological processes, little is known about their role...
7.
Kwon M, Chung H, Xiao L, Yu T, Wang S, Piao J, et al.
Am J Physiol Cell Physiol
. 2021 Mar;
320(6):C1042-C1054.
PMID: 33788631
Intestinal Tuft cells sense luminal contents to influence the mucosal immune response against eukaryotic infection. Paneth cells secrete antimicrobial proteins as part of the mucosal protective barrier. Defects in Tuft...
8.
Yu T, Chung H, Xiao L, Piao J, Lan S, Jaladanki S, et al.
Cell Mol Gastroenterol Hepatol
. 2019 Dec;
9(4):611-625.
PMID: 31862317
Background & Aims: The protective intestinal mucosal barrier consists of multiple elements including mucus and epithelial layers and immune defense; nonetheless, barrier dysfunction is common in various disorders. The imprinted...
9.
Zhang Y, Zhang Y, Xiao L, Yu T, Li J, Rao J, et al.
Mol Cell Biol
. 2017 Jul;
37(19).
PMID: 28716948
Insulin-like growth factor type 2 (IGF2) receptor (IGF2R) recognizes mannose 6-phosphate-containing molecules and IGF2 and plays an important role in many pathophysiological processes, including gut mucosal adaptation. However, the mechanisms...
10.
Yu T, Gu B, Yan J, Zhu J, Yan W, Chen J, et al.
Am J Physiol Cell Physiol
. 2015 Oct;
310(1):C54-65.
PMID: 26491048
The effectiveness and stability of epithelial barrier depend on apical junctional complexes, which consist of tight junctions (TJs) and adherens junctions (AJs). E-cadherin is the primary component of AJs, and...