Timothy V Olah
Overview
Explore the profile of Timothy V Olah including associated specialties, affiliations and a list of published articles.
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39
Citations
142
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Recent Articles
1.
Discenza L, Balog A, Huang C, Moore R, Ranasinghe A, Lin T, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2022 Jul;
1207:123305.
PMID: 35839627
BMS-986205 (Linrodostat) is a small molecule inhibitor of Indoleamine 2, 3 dioxygenase (IDO) that is currently being evaluated in clinical trials for the oral treatment of advanced cancer. Initially, there...
2.
Mehl J, Landry F, Discenza L, Sleczka B, Zhao Q, Shuster D, et al.
Bioanalysis
. 2021 Feb;
13(3):147-159.
PMID: 33543654
Surrogate monoclonal antibodies (mAbs) used in preclinical studies can be challenging to quantify due to lack of suitable immunoaffinity reagents or unavailability of the mAb protein sequence. Generic immunoaffinity reagents...
3.
Ranasinghe A, Ciccimaro Jr E, DArienzo C, Olah T, Ponath P, Hnatyshyn S
Rapid Commun Mass Spectrom
. 2021 Jan;
35(7):e9041.
PMID: 33415785
Rationale: Gangliosides (GS) are attractive targets in biomarker discovery because of their physiological significance in numerous human diseases including certain cancers and developmental and metabolic disorders. The robust strategy described...
4.
Caporuscio C, Holmes D, Olah T, Shipkova P
Bioanalysis
. 2020 Oct;
12(20):1439-1447.
PMID: 33006478
There is little information in the literature regarding assays for measuring CDH17 in tissues. Numerous studies indicate overexpression of CDH17 in a variety of diseases including hepatocellular carcinoma, colorectal and...
5.
Zhang H, Ciccimaro E, Zalaznick J, Sleczka B, Menard L, Olah T, et al.
Bioanalysis
. 2020 Sep;
12(18):1311-1324.
PMID: 32945691
S1PR1, a G protein-coupled receptor (GPCR) protein, is a therapeutic target for treatment of autoimmune diseases. As a potential biomarker for drug effect and patient stratification, it is of great...
6.
Wagner A, Zhang J, Liu C, Covey T, Olah T, Weller H, et al.
Anal Chem
. 2020 Sep;
92(19):13525-13531.
PMID: 32926623
Bioanalysis of polar analytes using liquid chromatography-tandem mass spectrometry (LC-MS/MS) remains a significant challenge because of their poor chromatographic retention on the commonly used reversed-phase LC columns and the resulting...
7.
Sleczka B, Levesque P, Adam L, Olah T, Shipkova P
Anal Biochem
. 2020 May;
602:113766.
PMID: 32389692
The S100A1 protein is a target of interest for the treatment of heart failure as it has been previously reported to be depleted in failing cardiomyocytes. A gene therapy approach...
8.
Neubert H, Shuford C, Olah T, Garofolo F, Schultz G, Jones B, et al.
Clin Chem
. 2020 Feb;
66(2):282-301.
PMID: 32040572
Immunoaffinity-mass spectrometry (IA-MS) is an emerging analytical genre with several advantages for profiling and determination of protein biomarkers. Because IA-MS combines affinity capture, analogous to ligand binding assays (LBAs), with...
9.
Shipkova P, Ciccimaro E, Olah T
Bioanalysis
. 2017 Nov;
9(23):1845-1847.
PMID: 29171760
No abstract available.
10.
Zhang H, Gu H, Shipkova P, Ciccimaro E, Sun H, Zhao Q, et al.
Bioanalysis
. 2017 Oct;
9(20):1573-1588.
PMID: 29072496
Aim: IP-10 is a protein target for the treatment of Crohn's disease. Inhibition of IP-10 by anti-IP-10 mAbs neutralizes its various biological activities. The measurement of free IP-10 suppression as...