Timothy R Zacharewski
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Explore the profile of Timothy R Zacharewski including associated specialties, affiliations and a list of published articles.
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69
Citations
1273
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Recent Articles
1.
Jurgelewicz A, Nault R, Harkema J, Zacharewski T, LaPres J
Sci Rep
. 2023 Oct;
13(1):16598.
PMID: 37789023
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with metabolic syndrome (MetS) in humans and elicits pathologies in rodents that resemble non-alcoholic fatty liver disease (NAFLD) in humans through activation of the aryl hydrocarbon...
2.
Orlowska K, Fling R, Nault R, Schilmiller A, Zacharewski T
Chem Res Toxicol
. 2023 May;
36(6):900-915.
PMID: 37184393
Exposure to 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) has been associated with the induction of oxidative stress and the progression of steatosis to steatohepatitis with fibrosis. It also disrupts metabolic pathways including one-carbon metabolism...
3.
Fling R, Zacharewski T
Int J Mol Sci
. 2021 Nov;
22(22).
PMID: 34830313
Gut dysbiosis with disrupted enterohepatic bile acid metabolism is commonly associated with non-alcoholic fatty liver disease (NAFLD) and recapitulated in a NAFLD-phenotype elicited by 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) in mice. TCDD induces...
4.
Cholico G, Fling R, Zacharewski N, Fader K, Nault R, Zacharewski T
Sci Rep
. 2021 Aug;
11(1):15689.
PMID: 34344994
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental contaminant, induces steatosis by increasing hepatic uptake of dietary and mobilized peripheral fats, inhibiting lipoprotein export, and repressing β-oxidation. In this study, the mechanism of...
5.
Josyula N, Andersen M, Kaminski N, Dere E, Zacharewski T, Bhattacharya S
Arch Toxicol
. 2019 Nov;
94(1):113-126.
PMID: 31728591
Four decades after its discovery, the aryl hydrocarbon receptor (AHR), a ligand-inducible transcription factor (TF) activated by the persistent environmental contaminant 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), remains an enigmatic molecule with a controversial...
6.
Dornbos P, Jurgelewicz A, Fader K, Williams K, Zacharewski T, LaPres J
Sci Rep
. 2019 Nov;
9(1):15828.
PMID: 31676775
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor. The prototypical ligand of the AHR is an environmental contaminant called 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD exposure is associated with many adverse...
7.
Fader K, Nault R, Doskey C, Fling R, Zacharewski T
Sci Rep
. 2019 Apr;
9(1):6514.
PMID: 31015483
Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of circadian clock regulators, however the impact on clock-controlled metabolism has not been thoroughly investigated. This study examines...
8.
Fader K, Nault R, Raehtz S, McCabe L, Zacharewski T
Toxicol Appl Pharmacol
. 2018 Apr;
348:85-98.
PMID: 29673856
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and other aryl hydrocarbon receptor (AhR) agonists have been shown to regulate bone development and remodeling in a species-, ligand-, and age-specific manner, however the underlying mechanisms remain...
9.
Fader K, Zacharewski T
Curr Opin Toxicol
. 2017 Sep;
2:36-41.
PMID: 28948239
2,3,7,8-Tetrachlorodibenzo--dioxin (TCDD) is the prototypical ligand for a group of environmental halogenated aromatic hydrocarbon contaminants which elicit hepatotoxicity and other toxic responses through activation of the aryl hydrocarbon receptor (AhR)....
10.
Fader K, Nault R, Zhang C, Kumagai K, Harkema J, Zacharewski T
Sci Rep
. 2017 Jul;
7(1):5921.
PMID: 28725001
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor (AhR). Male C57BL/6 mice orally gavaged with TCDD (0.01-30 µg/kg) every 4 days...