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» Authors » Timothy J Revett

Timothy J Revett

Explore the profile of Timothy J Revett including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 394
Followers 0
Related Specialties
Biochemistry
Psychiatry
Cell Biology
Top 10 Co-Authors
Gideon J Davies
Satyabrata Kar
Anthony J Turner
Nigel M Hooper
Monika Rella
Caroline Beckett
Richard M Jackson
Dianna J Bowles
Yanlin Wang
Joann L Elliot
Published In
J Biol Chem
Structure
BMC Genomics
J Proteome Res
Proc Natl Acad Sci U S A
Affiliations
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Recent Articles
1.
Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis
Amritraj A, Wang Y, Revett T, Vergote D, Westaway D, Kar S
J Biol Chem . 2012 Dec; 288(5):3136-52. PMID: 23250759
Cathepsin D is an aspartyl protease that plays a crucial role in normal cellular functions and in a variety of neurodegenerative disorders, including Niemann-Pick type C (NPC) disease, which is...
2.
Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology
Revett T, Baker G, Jhamandas J, Kar S
J Psychiatry Neurosci . 2012 Aug; 38(1):6-23. PMID: 22894822
Alzheimer disease is the most prevalent form of dementia globally and is characterized premortem by a gradual memory loss and deterioration of higher cognitive functions and postmortem by neuritic plaques...
3.
Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90
Knobbe C, Revett T, Bai Y, Chow V, Jeon A, Bohm C, et al.
J Proteome Res . 2011 Aug; 10(10):4388-404. PMID: 21819105
DJ-1 is a small but relatively abundant protein of unknown function that may undergo stress-dependent cellular translocation and has been implicated in both neurodegenerative diseases and cancer. As such, DJ-1...
4.
The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway
Belyaev N, Kellett K, Beckett C, Makova N, Revett T, Nalivaeva N, et al.
J Biol Chem . 2010 Oct; 285(53):41443-54. PMID: 20961856
Amyloidogenic processing of the amyloid precursor protein (APP) by β- and γ-secretases generates several biologically active products, including amyloid-β (Aβ) and the APP intracellular domain (AICD). AICD regulates transcription of...
5.
Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants
Brazier-Hicks M, Offen W, Gershater M, Revett T, Lim E, Bowles D, et al.
Proc Natl Acad Sci U S A . 2007 Dec; 104(51):20238-43. PMID: 18077347
The glucosylation of pollutant and pesticide metabolites in plants controls their bioactivity and the formation of subsequent chemical residues. The model plant Arabidopsis thaliana contains >100 glycosyltransferases (GTs) dedicated to...
6.
Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE
Rella M, Elliot J, Revett T, Lanfear J, Phelan A, Jackson R, et al.
BMC Genomics . 2007 Jun; 8:194. PMID: 17597519
Background: Mammalian angiotensin converting enzyme (ACE) plays a key role in blood pressure regulation. Although multiple ACE-like proteins exist in non-mammalian organisms, to date only one other ACE homologue, ACE2,...
7.
Structural and thermodynamic dissection of specific mannan recognition by a carbohydrate binding module, TmCBM27
Boraston A, Revett T, Boraston C, Nurizzo D, Davies G
Structure . 2003 Jun; 11(6):665-75. PMID: 12791255
The C-terminal 176 amino acids of a Thermotoga maritima mannanase (Man5) constitute a carbohydrate binding module (CBM) that has been classified into CBM family 27. The isolated CBM27 domain, named...