Timothy J Deming
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Explore the profile of Timothy J Deming including associated specialties, affiliations and a list of published articles.
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87
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2316
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Recent Articles
1.
Morrison C, Chan E, Deming T
J Am Chem Soc
. 2025 Feb;
147(9):7617-7623.
PMID: 39973289
We report the synthesis of amphiphilic poly(l-methionine sulfoxide)--poly(dehydroalanine), diblock copolypeptides, , and their self-assembly into submicrometer-diameter unilamellar vesicles in aqueous media. The formation of vesicles was observed over an unprecedented...
2.
Morrison C, Chan E, Lee T, Deming T
Biomacromolecules
. 2024 Mar;
25(4):2554-2562.
PMID: 38426942
Our group recently developed a family of side-chain amino acid-functionalized poly(S-alkyl-l-homocysteines), (Xaa = generic amino acid), which possess the ability to form environmentally responsive coacervates in water. In an effort...
3.
Deming T
Acc Chem Res
. 2024 Feb;
57(5):661-669.
PMID: 38373227
There is considerable recent interest in the synthesis and development of peptide-based materials as mimics of natural biological assemblies that utilize proteins and peptides to form organized structures and develop...
4.
Squair J, Milano M, de Coucy A, Gautier M, Skinnider M, James N, et al.
Science
. 2023 Sep;
381(6664):1338-1345.
PMID: 37733871
Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific...
5.
Benavides I, Scott W, Cai X, Zhou Z, Deming T
Eur Phys J E Soft Matter
. 2023 Sep;
46(9):81.
PMID: 37707598
We report development and preparation of synthetic polypeptide based, coacervate core polyelectrolyte complex micelles, PCMs, in aqueous media, which were characterized and evaluated for the encapsulation and in vitro release...
6.
Benavides I, Deming T
ACS Macro Lett
. 2023 Apr;
12(4):518-522.
PMID: 37014119
We report the preparation of a new water-soluble, nonionic homopolypeptide poly(l-homoserine) as well as poly(l-homoserine) block copolymers with controllable segment lengths. The conformational preferences of poly(l-homoserine) were also determined in...
7.
Sun Y, Bentolila L, Deming T
ACS Macro Lett
. 2022 Jun;
8(10):1275-1279.
PMID: 35651151
Multicomponent interpenetrating network hydrogels possessing enhanced mechanical stiffness compared to their individual components were prepared via physical mixing of diblock copolypeptides that assemble by either hydrophobic association or polyion complexation...
8.
Sun Y, Deming T
ACS Macro Lett
. 2022 May;
8(5):553-557.
PMID: 35619374
Diblock, triblock, and pentablock copolypeptides were designed and prepared for formation of polyion complex hydrogels in aqueous media. Increasing the number of block segments was found to allow formation of...
9.
Kramer J, Petitdemange R, Bataille L, Bathany K, Wirotius A, Garbay B, et al.
ACS Macro Lett
. 2022 May;
4(11):1283-1286.
PMID: 35614829
Tuning the lower critical solution temperature (LCST) of temperature-responsive recombinant elastin-like polypeptides has usually been achieved by designing different protein sequences, in terms of amino acid composition and length, implying...
10.
Negri G, Deming T
ACS Macro Lett
. 2022 May;
5(11):1253-1256.
PMID: 35614735
We have prepared a new l-lysine-based -carboxyanhydride monomer containing a photolabile -nitrobenzyloxycarbonyl protecting group. This monomer was used to prepare poly(l-lysine)--poly(oNB-l-lysine) block copolypeptides that formed hydrogels with tunable physical properties...