Timothy H Marczylo
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Explore the profile of Timothy H Marczylo including associated specialties, affiliations and a list of published articles.
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34
Citations
1073
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Recent Articles
1.
Bowsher R, Marczylo T, Gooch K, Bailey A, Wright M, Marczylo E
Eur Respir J
. 2024 Jul;
64(1.
PMID: 38991709
Background: Evidence for the impact of smoking on coronavirus disease 2019 (COVID-19) is contradictory, and there is little research on vaping. Here we provide greater clarity on mechanisms perturbed by...
2.
Ayakannu T, Taylor A, Marczylo T, Maccarrone M, Konje J
Front Oncol
. 2019 Jun;
9:430.
PMID: 31245282
To identify new biochemical markers for endometrial cancer (EC). Recent evidence suggests that members of the endocannabinoid system (-acylethanolamines) that bind to and activate receptors that are dysregulated in EC...
3.
Ayakannu T, Taylor A, Marczylo T, Konje J
Med Sci Monit Basic Res
. 2019 Mar;
25:76-87.
PMID: 30842391
BACKGROUND The aim of this study was to determine if components of the endocannabinoid system are modulated in uterine leiomyomas (fibroids). Components studied included cannabinoid receptors 1 (CB1) and 2...
4.
Bambang K, Karasu T, Gebeh A, Taylor A, Marczylo T, Lam P, et al.
Pharmaceuticals (Basel)
. 2016 Oct;
3(9):2910-2929.
PMID: 27713383
There is an increasing recognition that the endocannabinoid system is the crucial cytokine-hormone system regulating early human pregnancy. The synchronous development of the fertilized embryo and the endometrium to ensure...
5.
Karasu T, Marczylo T, Marczylo E, Taylor A, Oloto E, Konje J
J Clin Endocrinol Metab
. 2014 Jan;
99(3):871-80.
PMID: 24423290
Introduction: High anandamide (AEA) concentrations are detrimental for implantation and early pregnancy. Progesterone, essential for pregnancy, may keep AEA levels low by increasing fatty acid amide hydrolase (FAAH) expression. Here...
6.
Ayakannu T, Taylor A, Marczylo T, Willets J, Konje J
Int J Endocrinol
. 2013 Dec;
2013:259676.
PMID: 24369462
The "endocannabinoid system (ECS)" comprises the endocannabinoids, the enzymes that regulate their synthesis and degradation, the prototypical cannabinoid receptors (CB1 and CB2), some noncannabinoid receptors, and an, as yet, uncharacterised...
7.
Gebeh A, Willets J, Marczylo T, Konje J
J Matern Fetal Neonatal Med
. 2013 Oct;
27(9):954-9.
PMID: 24117326
Objectives: Cannabinoids are effective antiemetics and the "endogenous cannabinoids" (endocannabinoids) are thought to modulate emesis in both humans and animal models. Endocannabinoids, their receptors and their metabolising enzymes are present...
8.
Varga A, Jenes A, Marczylo T, Sousa-Valente J, Chen J, Austin J, et al.
Pflugers Arch
. 2013 Oct;
466(7):1421-35.
PMID: 24114173
The endogenous lipid agent N-arachidonoylethanolamine (anandamide), among other effects, has been shown to be involved in nociceptive processing both in the central and peripheral nervous systems. Anandamide is thought to...
9.
Gervasi M, Marczylo T, Lam P, Rana S, Franchi A, Konje J, et al.
PLoS One
. 2013 Aug;
8(8):e72521.
PMID: 23977311
Mammalian oviduct acts as a reservoir for spermatozoa and provides an environment in which they may compete for the opportunity to fertilize the oocyte. Whilst in the oviduct spermatozoa undergo...
10.
Gebeh A, Willets J, Bari M, Hirst R, Marczylo T, Taylor A, et al.
J Clin Endocrinol Metab
. 2013 Feb;
98(3):1226-34.
PMID: 23372171
Background: Studies from knockout mice suggest that perturbations in oviductal endocannabinoid levels, endocannabinoid receptors, or endocannabinoid degrading enzyme [fatty acid amide hydrolase (FAAH)] expression result in infertility secondary to physical...