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Timothy B Niewold

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Articles 176
Citations 6453
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Recent Articles
11.
Bridges Jr S, Niewold T, Merriman T
Arthritis Rheumatol . 2022 May; 74(10):1612-1614. PMID: 35583794
No abstract available.
12.
Van Buren K, Li Y, Zhong F, Ding Y, Puranik A, Loomis C, et al.
J Immunol Methods . 2022 Feb; 505:113233. PMID: 35131237
Biopsies of inflammatory tissue contain a complex network of interacting cells, orchestrating the immune or autoimmune response. While standard histological examination can identify relationships, it is clear that a great...
13.
Nln I, Fernandez-Ruiz R, Wampler Muskardin T, Paredes J, Blazer A, Tuminello S, et al.
Transl Res . 2022 Feb; 244:47-55. PMID: 35114420
Type I interferon (IFN) is critical in our defense against viral infections. Increased type I IFN pathway activation is a genetic risk factor for systemic lupus erythematosus (SLE), and a...
14.
Fernandez-Ruiz R, Niewold T
J Invest Dermatol . 2022 Jan; 142(3 Pt B):793-803. PMID: 35016780
Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and dermatomyositis demonstrate enhanced IFN-1 signaling. IFN-1 excess...
15.
Ghodke-Puranik Y, Jin Z, Zimmerman K, Ainsworth H, Fan W, Jensen M, et al.
Arthritis Res Ther . 2021 Dec; 23(1):290. PMID: 34847931
Background: We performed expression quantitative trait locus (eQTL) analysis in single classical (CL) and non-classical (NCL) monocytes from patients with systemic lupus erythematosus (SLE) to quantify the impact of well-established...
16.
Iwamoto T, Dorschner J, Selvaraj S, Mezzano V, Jensen M, Vsetecka D, et al.
J Rheumatol . 2021 Nov; 49(4):388-397. PMID: 34782453
Objective: Previous studies suggest a link between high serum type I interferon (IFN) and lupus nephritis (LN). We determined whether serum IFN activity is associated with subtypes of LN and...
17.
Nln I, Fernandez-Ruiz R, Wampler Muskardin T, Paredes J, Blazer A, Tuminello S, et al.
medRxiv . 2021 Nov; PMID: 34751274
Background: We find that a number of IFN pathway lupus risk alleles significantly impact mortality following COVID-19 infection. These data support the idea that type I IFN pathway risk alleles...
18.
Frittoli R, Pereira D, Lapa A, Postal M, Sinicato N, Fernandes P, et al.
Rheumatology (Oxford) . 2021 Jul; 61(4):1529-1537. PMID: 34282445
Objective: Axonal/neuronal damage has been shown to be a pathological finding that precedes neuropsychiatric manifestations in SLE. The objective of this study was to determine the presence of axonal dysfunction...
19.
Paredes J, Fernandez-Ruiz R, Niewold T
Rheum Dis Clin North Am . 2021 Jul; 47(3):379-393. PMID: 34215369
T-cell dysregulation has been implicated in the loss of tolerance and overactivation of B cells in systemic lupus erythematosus (SLE). Recent studies have identified T-cell subsets and genetic, epigenetic, and...
20.
Kim S, Puranik A, Jiang K, Chen X, Zhu X, Taylor I, et al.
J Am Soc Nephrol . 2021 Jun; 32(8):1987-2004. PMID: 34135081
Background: Peripheral vascular diseases may induce chronic ischemia and cellular injury distal to the arterial obstruction. Cellular senescence involves proliferation arrest in response to stress, which can damage neighboring cells....