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Timo Laitio

Explore the profile of Timo Laitio including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 30
Citations 299
Followers 0
Related Specialties
Anesthesiology
Critical Care
Emergency Medicine
Top 10 Co-Authors
Markus B Skrifvars
Hans Kirkegaard
Eldar Soreide
Harry Scheinin
Fabio Silvio Taccone
Christian Storm
Anders M Grejs
Valdo Toome
Tero Vahlberg
Christian Hassager
Published In
Resuscitation
Anesth Analg
JAMA
Crit Care
Crit Care Explor
Affiliations
Soon will be listed here.
Recent Articles
1.
Potassium disorders at intensive care unit admission and functional outcomes after cardiac arrest
Holm A, Lascarrou J, Cariou A, Reinikainen M, Laitio T, Kirkegaard H, et al.
Resuscitation . 2024 Nov; 205:110439. PMID: 39577555
Background: Abnormal serum potassium levels are commonly found in the intensive care unit (ICU) population. We aimed to determine the prevalence of potassium disorders at ICU admission and its association...
2.
A metabolic profile of xenon and metabolite associations with 6-month mortality after out-of-hospital cardiac arrest: A post-hoc study of the randomised Xe-Hypotheca trial
Nummela A, Scheinin H, Perola M, Joensuu A, Laitio R, Arola O, et al.
PLoS One . 2024 Jun; 19(6):e0304966. PMID: 38833442
Purpose: Out-of-hospital cardiac arrest (OHCA) carries a relatively poor prognosis and requires multimodal prognostication to guide clinical decisions. Identification of previously unrecognized metabolic routes associated with patient outcome may contribute...
3.
Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials
Lascarrou J, Ermel C, Cariou A, Laitio T, Kirkegaard H, Soreide E, et al.
Crit Care . 2023 Dec; 27(1):472. PMID: 38041177
Purpose: To evaluate the potential association between early dysnatremia and 6-month functional outcome after cardiac arrest. Methods: We pooled data from four randomised clinical trials in post-cardiac-arrest patients admitted to...
4.
Circulating oxylipin and bile acid profiles of dexmedetomidine, propofol, sevoflurane, and S-ketamine: a randomised controlled trial using tandem mass spectrometry
Nummela A, Laaksonen L, Scheinin A, Kaisti K, Vahlberg T, Neuvonen M, et al.
BJA Open . 2023 Aug; 4:100114. PMID: 37588789
Background: This exploratory study aimed to investigate whether dexmedetomidine, propofol, sevoflurane, and S-ketamine affect oxylipins and bile acids, which are functionally diverse molecules with possible connections to cellular bioenergetics, immune...
5.
Effect of xenon on brain injury, neurological outcome, and survival in patients after aneurysmal subarachnoid hemorrhage-study protocol for a randomized clinical trial
Laaksonen M, Rinne J, Rahi M, Posti J, Laitio R, Kivelev J, et al.
Trials . 2023 Jun; 24(1):417. PMID: 37337295
Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a neurological emergency, affecting a younger population than individuals experiencing an ischemic stroke; aSAH is associated with a high risk of mortality and permanent...
6.
Decreased Thalamic Activity Is a Correlate for Disconnectedness during Anesthesia with Propofol, Dexmedetomidine and Sevoflurane But Not S-Ketamine
Kantonen O, Laaksonen L, Alkire M, Scheinin A, Langsjo J, Kallionpaa R, et al.
J Neurosci . 2023 May; 43(26):4884-4895. PMID: 37225435
Establishing the neural mechanisms responsible for the altered global states of consciousness during anesthesia and dissociating these from other drug-related effects remains a challenge in consciousness research. We investigated differences...
7.
Electrolyte profiles with induced hypothermia: A sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest
Kirkegaard H, Grejs A, Gudbjerg S, Duez C, Jeppesen A, Hassager C, et al.
Acta Anaesthesiol Scand . 2022 Feb; 66(5):615-624. PMID: 35218019
Background: Electrolyte disturbances can result from targeted temperature treatment (TTM) in out-of-hospital cardiac arrest (OHCA) patients. This study explores electrolyte changes in blood and urine in OHCA patients treated with...
8.
On no man's land: Subjective experiences during unresponsive and responsive sedative states induced by four different anesthetic agents
Radek L, Koskinen L, Sandman N, Laaksonen L, Kallionpaa R, Scheinin A, et al.
Conscious Cogn . 2021 Nov; 96:103239. PMID: 34801782
To understand how anesthetics with different molecular mechanisms affect consciousness, we explored subjective experiences recalled after responsive and unresponsive sedation induced with equisedative doses of dexmedetomidine, propofol, sevoflurane, and S-ketamine...
9.
Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest-A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial
Saraste A, Ballo H, Arola O, Laitio R, Airaksinen J, Hynninen M, et al.
Crit Care Explor . 2021 Aug; 3(8):e0502. PMID: 34345828
Design: A randomized two-group single-blinded phase 2 clinical drug trial. Setting: A multipurpose ICU in two university hospitals. Patients: Of the 110 randomized comatose survivors after out-of-hospital cardiac arrest with...
10.
Factors Associated With Rebound Hyperthermia After Targeted Temperature Management in Out-of-Hospital Cardiac Arrest Patients: An Explorative Substudy of the Time-Differentiated Therapeutic Hypothermia in Out-of-Hospital Cardiac Arrest Survivors...
Holm A, Kirkegaard H, Taccone F, Soreide E, Grejs A, Toome V, et al.
Crit Care Explor . 2021 Jul; 3(7):e0458. PMID: 34250498
Design: Post hoc analysis. Setting: Ten European ICUs. Patients: Patients included in the time-differentiated therapeutic hypothermia in out-of-hospital cardiac arrest survivors trial treated with targeted temperature management at 33°C for...