Tim R Dafforn
Overview
Explore the profile of Tim R Dafforn including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
31
Citations
533
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Bruque M, Rodger A, Vronning Hoffmann S, Jones N, Aucamp J, Dafforn T, et al.
Anal Chem
. 2024 Sep;
PMID: 39255385
Understanding the impact of the manufacturing environment on therapeutic monoclonal antibody (mAb) structures requires new process analytical technology. Here, we describe the creation of a new reference set for the...
2.
Wang X, Slater A, Lee S, Harrison N, Pollock N, Bakker S, et al.
Arch Biochem Biophys
. 2024 Feb;
754:109944.
PMID: 38395124
The collagen/fibrin(ogen) receptor, glycoprotein VI (GPVI), is a platelet activating receptor and a promising anti-thrombotic drug target. However, while agonist-induced GPVI clustering on platelet membranes has been shown to be...
3.
Ayub H, Murray R, Kuyler G, Napier-Khwaja F, Gunner J, Dafforn T, et al.
Arch Biochem Biophys
. 2024 Feb;
754:109946.
PMID: 38395122
G-protein-coupled receptors (GPCRs) are the largest family of membrane proteins, regulate a plethora of physiological responses and are the therapeutic target for 30-40% of clinically-prescribed drugs. They are integral membrane...
4.
Hall S, Tognoloni C, Campbell R, Richens J, OShea P, Terry A, et al.
J Colloid Interface Sci
. 2022 Jun;
625:220-236.
PMID: 35716617
Hypothesis: Self-assembly of amphipathic styrene maleic acid copolymers with phospholipids in aqueous solution results in the formation of 'nanodiscs' containing a planar segment of phospholipid bilayer encapsulated by a polymer...
5.
Nestorow S, Dafforn T, Frasca V
Biochem Soc Trans
. 2021 Oct;
49(5):2037-2050.
PMID: 34643233
Membrane proteins such as receptors, ion channels and transport proteins are important drug targets. The structure-based study of membrane proteins is challenging, especially when the target protein contains both soluble...
6.
Grime R, Logan R, Nestorow S, Sridhar P, Edwards P, Tate C, et al.
Nanoscale
. 2021 Sep;
13(31):13519-13528.
PMID: 34477756
Membrane proteins are of fundamental importance to cellular processes and nano-encapsulation strategies that preserve their native lipid bilayer environment are particularly attractive for studying and exploiting these proteins. Poly(styrene-co-maleic acid)...
7.
Quesnay J, Pollock N, Nagampalli R, Lee S, Balakrishnan V, Dias S, et al.
Biology (Basel)
. 2020 Nov;
9(11).
PMID: 33227948
The molecular identity of the mitochondrial pyruvate carrier (MPC) was presented in 2012, forty years after the active transport of cytosolic pyruvate into the mitochondrial matrix was first demonstrated. An...
8.
Hothersall J, Jones A, Dafforn T, Perrior T, Chapman K
Drug Discov Today
. 2020 Aug;
PMID: 32835806
G-protein-coupled receptor (GPCR) drug research is presently hindered by the technical challenges associated with generating purified receptors. Consequently, the application of critical modern discovery technologies has been limited, and the...
9.
10.
Hall S, Clifton L, Tognoloni C, Morrison K, Knowles T, Kinane C, et al.
J Colloid Interface Sci
. 2020 Apr;
574:272-284.
PMID: 32330753
Over recent years, there has been a rapid development of membrane-mimetic systems to encapsulate and stabilize planar segments of phospholipid bilayers in solution. One such system has been the use...