Tim Krischuns
Overview
Explore the profile of Tim Krischuns including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
113
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Recent Articles
1.
Arragain B, Krischuns T, Pelosse M, Drncova P, Blackledge M, Naffakh N, et al.
Nat Commun
. 2024 Aug;
15(1):6910.
PMID: 39160148
Replication of influenza viral RNA depends on at least two viral polymerases, a parental replicase and an encapsidase, and cellular factor ANP32. ANP32 comprises an LRR domain and a long...
2.
Dupont M, Krischuns T, Giai Gianetto Q, Paisant S, Bonazza S, Brault J, et al.
Nucleic Acids Res
. 2024 Apr;
52(12):7188-7210.
PMID: 38686810
Genome-wide approaches have significantly advanced our knowledge of the repertoire of RNA-binding proteins (RBPs) that associate with cellular polyadenylated mRNAs within eukaryotic cells. Recent studies focusing on the RBP interactomes...
3.
Krischuns T, Arragain B, Isel C, Paisant S, Budt M, Wolff T, et al.
Nat Commun
. 2024 Feb;
15(1):1064.
PMID: 38316757
The current model is that the influenza virus polymerase (FluPol) binds either to host RNA polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its...
4.
Schimunek J, Seidl P, Elez K, Hempel T, Le T, Noe F, et al.
Mol Inform
. 2023 Oct;
43(1):e202300262.
PMID: 37833243
The COVID-19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient...
5.
Camacho-Zarco A, Yu L, Krischuns T, Dedeoglu S, Maurin D, Bouvignies G, et al.
J Am Chem Soc
. 2023 Sep;
145(38):20985-21001.
PMID: 37707433
Adaptation of avian influenza RNA polymerase (FluPol) to human cells requires mutations on the 627-NLS domains of the PB2 subunit. The E627K adaptive mutation compensates a 33-amino-acid deletion in the...
6.
Hassan H, Chiavaralli J, Hassan A, Bedda L, Krischuns T, Chen K, et al.
RSC Med Chem
. 2023 Mar;
14(3):507-519.
PMID: 36970153
A naturally inspired chemical library of 25 molecules was synthesised guided by 3-D dimensionality and natural product likeness factors to explore a new chemical space. The synthesised chemical library, consisting...
7.
Gunl F, Krischuns T, Schreiber J, Henschel L, Wahrenburg M, Drexler H, et al.
Nat Commun
. 2023 Feb;
14(1):787.
PMID: 36774438
During influenza A virus (IAV) infections, viral proteins are targeted by cellular E3 ligases for modification with ubiquitin. Here, we decipher and functionally explore the ubiquitination landscape of the IAV...
8.
Krischuns T, Isel C, Drncova P, Lukarska M, Pflug A, Paisant S, et al.
PLoS Pathog
. 2023 Jan;
19(1):e1011073.
PMID: 36598907
[This corrects the article DOI: 10.1371/journal.ppat.1010328.].
9.
Krischuns T, Isel C, Drncova P, Lukarska M, Pflug A, Paisant S, et al.
PLoS Pathog
. 2022 May;
18(5):e1010328.
PMID: 35605026
During annual influenza epidemics, influenza B viruses (IBVs) co-circulate with influenza A viruses (IAVs), can become predominant and cause severe morbidity and mortality. Phylogenetic analyses suggest that IAVs (primarily avian...
10.
Krischuns T, Lukarska M, Naffakh N, Cusack S
Annu Rev Biochem
. 2021 Mar;
90:321-348.
PMID: 33770447
Influenza virus RNA-dependent RNA polymerase (FluPol) transcribes the viral RNA genome in the infected cell nucleus. In the 1970s, researchers showed that viral transcription depends on host RNA polymerase II...