Alexander Pflug
Overview
Explore the profile of Alexander Pflug including associated specialties, affiliations and a list of published articles.
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23
Citations
949
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Recent Articles
1.
Shields J, Baker D, Balazs A, Bommakanti G, Casella R, Cao S, et al.
J Med Chem
. 2025 Feb;
68(4):4582-4595.
PMID: 39928839
Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the T cell receptor signaling pathway and is therefore a target of interest for immunooncology. Nonselective HPK1 inhibitors may affect...
2.
Krischuns T, Isel C, Drncova P, Lukarska M, Pflug A, Paisant S, et al.
PLoS Pathog
. 2023 Jan;
19(1):e1011073.
PMID: 36598907
[This corrects the article DOI: 10.1371/journal.ppat.1010328.].
3.
Edwardes L, Caswell S, Giurrandino M, Zhai X, Gohlke A, Kostomiris D, et al.
Biochemistry
. 2022 Sep;
61(18):1974-1987.
PMID: 36070615
Human lysine methyltransferase 2D (hKMT2D) is an epigenetic writer catalyzing the methylation of histone 3 lysine 4. hKMT2D by itself has little catalytic activity and reaches full activation as part...
4.
Krischuns T, Isel C, Drncova P, Lukarska M, Pflug A, Paisant S, et al.
PLoS Pathog
. 2022 May;
18(5):e1010328.
PMID: 35605026
During annual influenza epidemics, influenza B viruses (IBVs) co-circulate with influenza A viruses (IAVs), can become predominant and cause severe morbidity and mortality. Phylogenetic analyses suggest that IAVs (primarily avian...
5.
Pieroh P, Hohmann T, Gras F, Mardian S, Pflug A, Wittenberg S, et al.
Sci Rep
. 2022 Feb;
12(1):2326.
PMID: 35149706
Treatment recommendations for fragility fractures of the pelvis (FFP) have been provided along with the good reliable FFP classification but they are not proven in large studies and recent reports...
6.
Wilharm A, Pflug A, Loos F, Sommerfeld O, Hofmann G, Sauer S
Z Orthop Unfall
. 2021 Dec;
161(3):297-303.
PMID: 34963187
Hintergrund: Trauma ist die häufigste Todesursache bei unter 45-Jährigen und trotzdem gibt es nur wenig Daten zu den genauen Todesursachen Schwerverletzter nach Klinikeinlieferung in Deutschland aus den letzten 10 Jahren....
7.
McCoull W, Boyd S, Brown M, Coen M, Collingwood O, Davies N, et al.
J Med Chem
. 2021 Sep;
64(18):13524-13539.
PMID: 34478292
Inhibition of Mer and Axl kinases has been implicated as a potential way to improve the efficacy of current immuno-oncology therapeutics by restoring the innate immune response in the tumor...
8.
Nissink J, Bazzaz S, Blackett C, Clark M, Collingwood O, Disch J, et al.
J Med Chem
. 2021 Mar;
64(6):3165-3184.
PMID: 33683117
Mer is a member of the TAM (Tyro3, Axl, Mer) kinase family that has been associated with cancer progression, metastasis, and drug resistance. Their essential function in immune homeostasis has...
9.
Pflug A, Schimpl M, Nissink J, Overman R, Rawlins P, Truman C, et al.
Biochem J
. 2020 Oct;
477(22):4443-4452.
PMID: 33119085
The activation loop (A-loop) plays a key role in regulating the catalytic activity of protein kinases. Phosphorylation in this region enhances the phosphoryl transfer rate of the kinase domain and...
10.
Wandzik J, Kouba T, Karuppasamy M, Pflug A, Drncova P, Provaznik J, et al.
Cell
. 2020 Apr;
181(4):877-893.e21.
PMID: 32304664
Influenza polymerase uses unique mechanisms to synthesize capped and polyadenylated mRNAs from the genomic viral RNA (vRNA) template, which is packaged inside ribonucleoprotein particles (vRNPs). Here, we visualize by cryoelectron...