Tim Fryer
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Explore the profile of Tim Fryer including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
208
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Recent Articles
1.
Maccioni L, Brusaferri L, Barzon L, Schubert J, Nettis M, Cousins O, et al.
Res Sq
. 2025 Feb;
PMID: 39975931
Positron Emission Tomography (PET) of the 18 kDa translocator protein (TSPO) is critical for neuroinflammation studies but faces substantial methodological challenges. These include issues with arterial blood sampling for kinetic...
2.
McLachlan M, Bettcher B, McVea A, DiFillipo A, Zammit M, LeMerise L, et al.
medRxiv
. 2024 Dec;
PMID: 39677434
Introduction: Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [C]PiB PET imaging, which has not been replicated with [F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with...
3.
Santangelo A, Sawiak S, Fryer T, Hong Y, Shiba Y, Clarke H, et al.
Proc Natl Acad Sci U S A
. 2019 Jul;
116(29):14761-14768.
PMID: 31266890
Genetic variation in the serotonin transporter gene () is associated with vulnerability to affective disorders and pharmacotherapy efficacy. We recently identified sequence polymorphisms in the common marmoset repeat region (AC/C/G...
4.
Bevan-Jones W, Cope T, Jones P, Passamonti L, Hong Y, Fryer T, et al.
Ann Clin Transl Neurol
. 2019 Mar;
6(2):373-378.
PMID: 30847369
Neuroinflammation occurs in frontotemporal dementia, however its timing relative to protein aggregation and neuronal loss is unknown. Using positron emission tomography and magnetic resonance imaging to quantify these processes in...
5.
Bevan-Jones R, Cope T, Jones S, Passamonti L, Hong Y, Fryer T, et al.
Ann Clin Transl Neurol
. 2018 Oct;
5(10):1292-1296.
PMID: 30349864
The PET ligand [F]AV-1451 was developed to bind tau pathology in Alzheimer's disease, but increased binding has been shown in both genetic tauopathies and in semantic dementia, a disease strongly...
6.
Price C, Wang D, Menon D, Guadagno J, Cleij M, Fryer T, et al.
Stroke
. 2006 Jun;
37(7):1749-53.
PMID: 16763188
Background And Purpose: Microglial activation is an important component of the neuroinflammatory response to ischemic stroke. Experimental studies have outlined such patterns temporally and spatially. In vivo studies in stroke...
7.
Owler B, Pena A, Momjian S, Czosnyka Z, Czosnyka M, Harris N, et al.
J Cereb Blood Flow Metab
. 2004 May;
24(5):579-87.
PMID: 15129190
The combination of cerebral blood flow measurement using (15)O-water positron emission tomography with magnetic resonance coregistration and CSF infusion studies was used to study the global and regional changes in...
8.
Owler B, Momjian S, Czosnyka Z, Czosnyka M, Pena A, Harris N, et al.
J Cereb Blood Flow Metab
. 2003 Dec;
24(1):17-23.
PMID: 14688613
Regional cerebral blood flow (CBF) was studied with O(15)-water positron emission tomography and anatomic region-of-interest analysis on co-registered magnetic resonance in patients with idiopathic (n = 12) and secondary (n...
9.
Gupta A, Hutchinson P, Fryer T, Al-Rawi P, Parry D, Minhas P, et al.
J Neurosurg
. 2002 Feb;
96(2):263-8.
PMID: 11838800
Object: The benefits of measuring cerebral oxygenation in patients with brain injury are well accepted; however, jugular bulb oximetry, which is currently the most popular monitoring technique used has several...