Tilo Freiwald
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Explore the profile of Tilo Freiwald including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
505
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0
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Recent Articles
1.
Dreher L, Bode M, Ehnert N, Meyer-Schwesinger C, Wiech T, Kohl J, et al.
Am J Hypertens
. 2024 Jun;
37(10):810-825.
PMID: 38934290
Backround: Complement activation may facilitate hypertension through its effects on immune responses. The anaphylatoxin C5a, a major inflammatory effector, binds to the C5a receptors 1 and 2 (C5aR1, C5aR2). We...
2.
Desai J, Kumar D, Freiwald T, Chauss D, Johnson M, Abers M, et al.
Cell
. 2023 May;
186(13):2802-2822.e22.
PMID: 37220746
Systemic candidiasis is a common, high-mortality, nosocomial fungal infection. Unexpectedly, it has emerged as a complication of anti-complement C5-targeted monoclonal antibody treatment, indicating a critical niche for C5 in antifungal...
3.
Bibby J, Agarwal D, Freiwald T, Kunz N, Merle N, West E, et al.
Cell Rep
. 2022 Nov;
41(8):111697.
PMID: 36417885
Pathway analysis is a key analytical stage in the interpretation of omics data, providing a powerful method for detecting alterations in cellular processes. We recently developed a sensitive and distribution-free...
4.
Niyonzima N, Rahman J, Kunz N, West E, Freiwald T, Desai J, et al.
Sci Immunol
. 2021 Dec;
6(66):eabf2489.
PMID: 34932384
While serum-circulating complement destroys invading pathogens, intracellularly active complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic events underlying T cell effector responses. Whether intracellular complement is also...
5.
Freiwald T, Afzali B
Adv Immunol
. 2021 Nov;
152:1-81.
PMID: 34844708
The complement system is an ancient and phylogenetically conserved key danger sensing system that is critical for host defense against pathogens. Activation of the complement system is a vital component...
6.
Chauss D, Freiwald T, McGregor R, Yan B, Wang L, Nova-Lamperti E, et al.
Nat Immunol
. 2021 Nov;
23(1):62-74.
PMID: 34764490
The molecular mechanisms governing orderly shutdown and retraction of CD4 type 1 helper T (T1) cell responses remain poorly understood. Here we show that complement triggers contraction of T1 responses...
7.
Break T, Oikonomou V, Dutzan N, Desai J, Swidergall M, Freiwald T, et al.
Science
. 2021 Sep;
373(6561):eabi8835.
PMID: 34529475
Puel and Casanova and Kisand . challenge our conclusions that interferonopathy and not IL-17/IL-22 autoantibodies promote candidiasis in autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy. We acknowledge that conclusive evidence for causation is difficult...
8.
Arcari L, Engel J, Freiwald T, Zhou H, Zainal H, Gawor M, et al.
J Cardiovasc Magn Reson
. 2021 Jun;
23(1):71.
PMID: 34092229
Background: High sensitivity cardiac troponin T (hs-cTnT) and NT-pro-brain natriuretic peptide (NT-pro BNP) are often elevated in chronic kidney disease (CKD) and associated with both cardiovascular remodeling and outcome. Relationship...
9.
Yan B, Freiwald T, Chauss D, Wang L, West E, Mirabelli C, et al.
Sci Immunol
. 2021 Apr;
6(58).
PMID: 33827897
Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical manifestations affecting the lungs, liver, kidneys and gut. Angiotensin converting enzyme (ACE) 2, the best-characterized entry receptor...
10.
Break T, Oikonomou V, Dutzan N, Desai J, Swidergall M, Freiwald T, et al.
Science
. 2021 Jan;
371(6526).
PMID: 33446526
Human monogenic disorders have revealed the critical contribution of type 17 responses in mucosal fungal surveillance. We unexpectedly found that in certain settings, enhanced type 1 immunity rather than defective...