Tilman Ziegler
Overview
Explore the profile of Tilman Ziegler including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
449
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0
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Recent Articles
1.
Kupatt C, Ziegler T, Bahr A, le Noble F
Int Immunopharmacol
. 2023 Feb;
117:109786.
PMID: 36812671
Since clinical revascularization techniques of coronary or peripheral artery disease (CAD/PAD) focus on macrovessels of the heart, the microcirculatory compartment largely goes unnoticed. However, cardiovascular risk factors not only drive...
2.
Ziegler T, Bozoglu T, Kupatt C
Methods Mol Biol
. 2022 Aug;
2573:63-74.
PMID: 36040587
Here we describe a protocol to produce a recombinant adeno-associated viral vector (rAAV)-based system to deliver the CRISPR-Cas9 complex into porcine skeletal muscle and myocardial cells. We initially describe the...
3.
Bozoglu T, Lee S, Ziegler T, Jurisch V, Maas S, Baehr A, et al.
Adv Sci (Weinh)
. 2022 Jan;
9(7):e2103867.
PMID: 35023328
Adeno-associated viruses (AAVs) are frequently used for gene transfer and gene editing in vivo, except for endothelial cells, which are remarkably resistant to unmodified AAV-transduction. AAVs are retargeted here toward...
4.
Neiburga K, Vilne B, Bauer S, Bongiovanni D, Ziegler T, Lachmann M, et al.
Biomolecules
. 2021 Nov;
11(11).
PMID: 34827683
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression. While microRNAs (miRs) have been well studied...
5.
Zimmermann G, Palm J, Lahmann A, Peltz F, Okrojek R, Weis F, et al.
J Clin Med
. 2021 Jul;
10(14).
PMID: 34300221
Background: Patients suffering from out-of-hospital cardiac arrest (OHCA) frequently receive a bronchoscopy after being admitted to the ICU. We investigated the optimal timing and the outcome in these patients. Methods:...
6.
AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction
Hinkel R, Batkai S, Bahr A, Bozoglu T, Straub S, Borchert T, et al.
J Am Coll Cardiol
. 2021 Jun;
77(23):2923-2935.
PMID: 34112319
Background: Pathological cardiac hypertrophy is a result of afterload-increasing pathologies including untreated hypertension and aortic stenosis. It features progressive adverse cardiac remodeling, myocardial dysfunction, capillary rarefaction, and interstitial fibrosis often...
7.
Fenske S, Hennis K, Rotzer R, Brox V, Becirovic E, Scharr A, et al.
Nat Commun
. 2020 Nov;
11(1):5555.
PMID: 33144559
It is highly debated how cyclic adenosine monophosphate-dependent regulation (CDR) of the major pacemaker channel HCN4 in the sinoatrial node (SAN) is involved in heart rate regulation by the autonomic...
8.
Abdel Rahman F, dAlmeida S, Zhang T, Asadi M, Bozoglu T, Bongiovanni D, et al.
Thromb Haemost
. 2020 Oct;
121(3):341-350.
PMID: 33011963
The high mortality seen in sepsis is caused by a systemic hypotension in part owing to a drastic increase in vascular permeability accompanied by a loss of pericytes. As has...
9.
Ziegler T, Laugwitz K, Kupatt C
Methods Mol Biol
. 2020 Aug;
2158:33-41.
PMID: 32857363
Left ventricular catheterization in mice allows for in-depth assessment of myocardial function in healthy and diseased animals with the advent of pressure volume loop recordings greatly enhancing the technique. While...
10.
Samarelli A, Ziegler T, Meves A, Fassler R, Bottcher R
J Cell Sci
. 2020 Aug;
133(18).
PMID: 32843574
Integrin function depends on the continuous internalization of integrins and their subsequent endosomal recycling to the plasma membrane to drive adhesion dynamics, cell migration and invasion. Here we assign a...