Tilman Sauerbruch
Overview
Explore the profile of Tilman Sauerbruch including associated specialties, affiliations and a list of published articles.
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270
Citations
5003
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Recent Articles
31.
Klein S, Herath C, Schierwagen R, Grace J, Haltenhof T, Uschner F, et al.
PLoS One
. 2015 Sep;
10(9):e0138732.
PMID: 26406236
Background & Aims: Although in cirrhosis with portal hypertension levels of the vasoconstrictor angiotensin II are increased, this is accompanied by increased production of angiotensin (Ang)-(1-7), the endogenous ligand of...
32.
Klein S, Rick J, Lehmann J, Schierwagen R, Schierwagen I, Verbeke L, et al.
Gut
. 2015 Sep;
66(1):145-155.
PMID: 26385087
Objective: Angiotensin II (AngII) activates via angiotensin-II-type-I receptor (AT1R) Janus-kinase-2 (JAK2)/Arhgef1 pathway and subsequently RHOA/Rho-kinase (ROCK), which induces experimental and probably human liver fibrosis. This study investigated the relationship of...
33.
Schierwagen R, Maybuchen L, Zimmer S, Hittatiya K, Back C, Klein S, et al.
Sci Rep
. 2015 Aug;
5:12931.
PMID: 26263022
Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis, inflammation and fibrosis, which might progress to cirrhosis. Human NASH is associated with metabolic syndrome (MS). Currently, rodent NASH models either lack...
34.
Berres M, Lehmann J, Jansen C, Gortzen J, Meyer C, Thomas D, et al.
Liver Int
. 2015 Jul;
36(3):386-94.
PMID: 26212075
Background & Aims: Chemokines, such as CXCR3-ligands, have been identified to play an important role during hepatic injury, inflammation and fibrosis. While CXCL9 is associated with survival in patients receiving...
35.
Lutz P, Pfarr K, Nischalke H, Kramer B, Goeser F, Glassner A, et al.
Clin Chem Lab Med
. 2015 Jun;
53(12):2031-9.
PMID: 26035112
Background: Diagnosis of spontaneous bacterial peritonitis (SBP) is based on a differential ascites leukocyte count which does not provide prognostic information. We performed a pilot study to assess calprotectin in...
36.
Sauerbruch T, Mengel M, Dollinger M, Zipprich A, Rossle M, Panther E, et al.
Gastroenterology
. 2015 May;
149(3):660-8.e1.
PMID: 25989386
Background & Aims: Patients with cirrhosis and variceal hemorrhage have a high risk of rebleeding. We performed a prospective randomized trial to compare the prevention of rebleeding in patients given...
37.
Kreisel W, Deibert P, Kupcinskas L, Sumskiene J, Appenrodt B, Roth S, et al.
Dig Liver Dis
. 2014 Dec;
47(2):144-50.
PMID: 25483910
Background: Phosphodiesterase-5-inhibitors may lower portal pressure. Aims: To investigate the effect of the phosphodiesterase-5-inhibitor udenafil on hepatic and systemic haemodynamics in liver cirrhosis. Methods: In an open-label phase-II-study, patients with...
38.
Berres M, Asmacher S, Lehmann J, Jansen C, Gortzen J, Klein S, et al.
J Hepatol
. 2014 Dec;
62(2):332-9.
PMID: 25457205
Background & Aims: Inflammation, collagen deposition and tissue remodelling are involved in the pathogenesis and complications of cirrhosis with portal hypertension. CXCL9 and other chemokines play an important role in...
39.
Sauerbruch T, Trebicka J
F1000Prime Rep
. 2014 Nov;
6:95.
PMID: 25374673
In patients with chronic liver disease, portal hypertension is driven by progressive fibrosis and intrahepatic vasoconstriction. Interruption of the initiating and perpetuating etiology-mostly leading to necroinflammation-is possible for several underlying...
40.
Lutz P, Berger C, Langhans B, Grunhage F, Appenrodt B, Nattermann J, et al.
Dig Liver Dis
. 2014 Aug;
46(11):1047-50.
PMID: 25086996
Background: In mice, the farnesoid X receptor is involved in bacterial translocation, which can result in spontaneous bacterial peritonitis in patients with cirrhosis. We investigated if polymorphisms in the farnesoid...