Till Wenger
Overview
Explore the profile of Till Wenger including associated specialties, affiliations and a list of published articles.
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17
Citations
799
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Recent Articles
1.
Greene E, Cazacu D, Tamot N, Castellano S, Datar A, Kronkaitis A, et al.
Biotechnol J
. 2020 Nov;
16(4):e2000251.
PMID: 33226178
Transient gene expression (TGE) using mammalian cells is an extensively used technology for the production of antibodies and recombinant proteins and has been widely adopted by both academic and industrial...
2.
Vcelar S, Melcher M, Auer N, Hrdina A, Puklowski A, Leisch F, et al.
Biotechnol J
. 2018 Jan;
13(3):e1700495.
PMID: 29328552
Chinese hamster ovary (CHO) cells are the number one production system for therapeutic proteins. A pre-requirement for their use in industrial production of biopharmaceuticals is to be clonal, thus originating...
3.
Vcelar S, Jadhav V, Melcher M, Auer N, Hrdina A, Sagmeister R, et al.
Biotechnol Bioeng
. 2017 Sep;
115(1):165-173.
PMID: 28921524
Genomic rearrangements are a common phenomenon in rapidly growing cell lines such as Chinese hamster ovary (CHO) cells, a feature that in the context of production of biologics may lead...
4.
Fieder J, Schulz P, Gorr I, Bradl H, Wenger T
Biotechnol J
. 2017 Apr;
12(6).
PMID: 28371300
The development of biopharmaceutical production cell lines typically starts with generation of heterogeneous populations of cells, from which then single cell clones are established. Several regulatory guidelines require that production...
5.
Pieper L, Strotbek M, Wenger T, Olayioye M, Hausser A
Biotechnol Bioeng
. 2017 Feb;
114(6):1310-1318.
PMID: 28165157
The dynamics of protein folding and secretion are key issues in improving the productivity and robustness of Chinese hamster ovary (CHO) producer cells. High recombinant protein secretion in CHO producer...
6.
Pieper L, Strotbek M, Wenger T, Gamer M, Olayioye M, Hausser A
Metab Eng
. 2017 Jan;
40:69-79.
PMID: 28088541
Chinese Hamster Ovary (CHO) cells are the most commonly used host for the production of biopharmaceuticals. Although transcription and translation engineering strategies have been employed to generate high-producer cell clones,...
7.
Terawaki S, Camosseto V, Prete F, Wenger T, Papadopoulos A, Rondeau C, et al.
J Cell Biol
. 2015 Sep;
210(7):1133-52.
PMID: 26416964
Autophagy is a key degradative pathway coordinated by external cues, including starvation, oxidative stress, or pathogen detection. Rare are the molecules known to contribute mechanistically to the regulation of autophagy...
8.
Clavarino G, Claudio N, Couderc T, Dalet A, Judith D, Camosseto V, et al.
PLoS Pathog
. 2012 May;
8(5):e1002708.
PMID: 22615568
Nucleic acid sensing by cells is a key feature of antiviral responses, which generally result in type-I Interferon production and tissue protection. However, detection of double-stranded RNAs in virus-infected cells...
9.
Wenger T, Terawaki S, Camosseto V, Abdelrassoul R, Mies A, Catalan N, et al.
Autophagy
. 2012 Mar;
8(3):350-63.
PMID: 22377621
A significant portion of newly synthesized protein fails to fold properly and is quickly degraded. These defective ribosomal products (DRiPs) are substrates for the ubiquitin-proteasome system (UPS) and give rise...
10.
Clavarino G, Claudio N, Dalet A, Terawaki S, Couderc T, Chasson L, et al.
Proc Natl Acad Sci U S A
. 2012 Feb;
109(8):3006-11.
PMID: 22315398
In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation that exhibits specific mechanisms to control the immune response. Here we show that in response to...