Tianyuan Lu
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Explore the profile of Tianyuan Lu including associated specialties, affiliations and a list of published articles.
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52
Citations
649
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Recent Articles
1.
Choi J, Cohen Kalafut N, Gruenloh T, Engelman C, Lu T, Wang D
bioRxiv
. 2025 Jan;
PMID: 39868220
Single-omics approaches often provide a limited view of complex biological systems, whereas multiomics integration offers a more comprehensive understanding by combining diverse data views. However, integrating heterogeneous data types and...
2.
Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Su C, Chen Y, et al.
Nat Genet
. 2025 Jan;
57(2):345-357.
PMID: 39856218
Obesity strongly increases the risk of cardiometabolic diseases, yet the underlying mediators of this relationship are not fully understood. Given that obesity strongly influences circulating protein levels, we investigated proteins...
3.
Lu T, Zhang W, Robinson-Cohen C, Engelman C, Lu Q, de Boer I, et al.
Am J Clin Nutr
. 2025 Jan;
121(3):731-740.
PMID: 39855341
Background: Understanding gene-environment interactions associated with vitamin D status may refine nutrition and public health strategies for vitamin D deficiency. Recent methodological advances have enabled the identification of variance quantitative...
4.
Lu T, Manousaki D, Sun L, Paterson A
Diabetes
. 2025 Jan;
PMID: 39761376
Circulating proteins may be promising biomarkers or drug targets. Leveraging genome-wide association studies of type 1 diabetes (18,942 cases and 501,638 controls of European ancestry) and circulating protein abundances (10,708...
5.
Zhang W, Su C, Yoshiji S, Lu T
Bioinformatics
. 2024 Nov;
40(11).
PMID: 39513749
Summary: Mendelian randomization is being utilized to assess causal effects of polygenic exposures, where many genetic instruments are subject to horizontal pleiotropy. Existing methods for detecting and correcting for horizontal...
6.
Miao J, Wu Y, Sun Z, Miao X, Lu T, Zhao J, et al.
Nat Genet
. 2024 Sep;
56(11):2361-2369.
PMID: 39349818
Machine learning (ML) has become increasingly popular in almost all scientific disciplines, including human genetics. Owing to challenges related to sample collection and precise phenotyping, ML-assisted genome-wide association study (GWAS),...
7.
Liu T, Liu J, Chen Q, Wu L, Zhang L, Qiao D, et al.
Medicine (Baltimore)
. 2024 Sep;
103(38):e39854.
PMID: 39312319
The extracellular matrix (ECM) is a complex and dynamic network of cross-linked proteins and a fundamental building block in multicellular organisms. Our study investigates the impact of genes related to...
8.
Austin T, Nethander M, Fink H, Tornqvist A, Jalal D, Buzkova P, et al.
Nat Aging
. 2024 Sep;
4(10):1508.
PMID: 39256542
No abstract available.
9.
A unified model for interpretable latent embedding of multi-sample, multi-condition single-cell data
Madrigal A, Lu T, Soto L, Najafabadi H
Nat Commun
. 2024 Aug;
15(1):6573.
PMID: 39097589
Single-cell analysis across multiple samples and conditions requires quantitative modeling of the interplay between the continuum of cell states and the technical and biological sources of sample-to-sample variability. We introduce...
10.
Ilboudo Y, Yoshiji S, Lu T, Butler-Laporte G, Zhou S, Richards J
J Alzheimers Dis
. 2024 May;
99(4):1243-1260.
PMID: 38820015
Background: Observational studies have found that vitamin D supplementation is associated with improved cognition. Further, recent Mendelian randomization (MR) studies have shown that higher vitamin D levels, 25(OH)D, may protect...