J Brent Richards
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Explore the profile of J Brent Richards including associated specialties, affiliations and a list of published articles.
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221
Citations
16027
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Recent Articles
1.
Tan D, Chen Y, Ilboudo Y, Liang K, Butler-Laporte G, Richards J
HGG Adv
. 2025 Jan;
6(2):100409.
PMID: 39861949
Identifying novel, high-yield drug targets is challenging and often results in a high failure rate. However, recent data indicate that leveraging human genetic evidence to identify and validate these targets...
2.
Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Su C, Chen Y, et al.
Nat Genet
. 2025 Jan;
57(2):345-357.
PMID: 39856218
Obesity strongly increases the risk of cardiometabolic diseases, yet the underlying mediators of this relationship are not fully understood. Given that obesity strongly influences circulating protein levels, we investigated proteins...
3.
Schmidt A, Casadei N, Brand F, Demidov G, Vojgani E, Abolhassani A, et al.
PLoS Pathog
. 2024 Dec;
20(12):e1012786.
PMID: 39715278
Courses of SARS-CoV-2 infections are highly variable, ranging from asymptomatic to lethal COVID-19. Though research has shown that host genetic factors contribute to this variability, cohort-based joint analyses of variants...
4.
Randolph H, Aguirre-Gamboa R, Brunet-Ratnasingham E, Nakanishi T, Locher V, Ketter E, et al.
bioRxiv
. 2024 Dec;
PMID: 39677792
Genome-wide association studies performed in patients with coronavirus disease 2019 (COVID-19) have uncovered various loci significantly associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity. However, the underlying -regulatory...
5.
Austin T, Nethander M, Fink H, Tornqvist A, Jalal D, Buzkova P, et al.
Nat Aging
. 2024 Sep;
4(10):1508.
PMID: 39256542
No abstract available.
6.
Chen Y, Butler-Laporte G, Liang K, Ilboudo Y, Yasmeen S, Sasako T, et al.
HGG Adv
. 2024 Aug;
5(4):100344.
PMID: 39180217
A novel algorithm, AlphaMissense, has been shown to have an improved ability to predict the pathogenicity of rare missense genetic variants. However, it is not known whether AlphaMissense improves the...
7.
Ilboudo Y, Yoshiji S, Lu T, Butler-Laporte G, Zhou S, Richards J
J Alzheimers Dis
. 2024 May;
99(4):1243-1260.
PMID: 38820015
Background: Observational studies have found that vitamin D supplementation is associated with improved cognition. Further, recent Mendelian randomization (MR) studies have shown that higher vitamin D levels, 25(OH)D, may protect...
8.
Austin T, Nethander M, Fink H, Tornqvist A, Jalal D, Buzkova P, et al.
Nat Aging
. 2024 May;
4(8):1064-1075.
PMID: 38802582
As there are effective treatments to reduce hip fractures, identification of patients at high risk of hip fracture is important to inform efficient intervention strategies. To obtain a new tool...
9.
Brunet-Ratnasingham E, Morin S, Randolph H, Labrecque M, Belair J, Lima-Barbosa R, et al.
Nat Commun
. 2024 May;
15(1):4177.
PMID: 38755196
Plasma RNAemia, delayed antibody responses and inflammation predict COVID-19 outcomes, but the mechanisms underlying these immunovirological patterns are poorly understood. We profile 782 longitudinal plasma samples from 318 hospitalized patients...
10.
Barrueta Tenhunen A, Butler-Laporte G, Yoshiji S, Morrison D, Nakanishi T, Chen Y, et al.
Physiol Genomics
. 2024 May;
56(7):483-491.
PMID: 38738317
Hypertonic dehydration is associated with muscle wasting and synthesis of organic osmolytes. We recently showed a metabolic shift to amino acid production and urea cycle activation in coronavirus-2019 (COVID-19), consistent...