Tianjin Shen
Overview
Explore the profile of Tianjin Shen including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
134
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0
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Recent Articles
1.
Zhong X, Tai W, Liu M, Ma S, Shen T, Zou Y, et al.
Neural Regen Res
. 2024 Sep;
20(11):3233-3244.
PMID: 39314140
JOURNAL/nrgr/04.03/01300535-202511000-00027/figure1/v/2024-12-20T164640Z/r/image-tiff The mitogen-activated protein kinase kinase kinase kinases (MAP4Ks) signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following insults. Whether targeting this pathway is beneficial to...
2.
Serrano C, Cananzi S, Shen T, Wang L, Zhang C
iScience
. 2024 Sep;
27(9):110706.
PMID: 39297168
Microglia, as the immune cells of the central nervous system (CNS), play dynamic roles in both healthy and diseased conditions. The ability to genetically target microglia using viruses is crucial...
3.
Serrano C, Cananzi S, Shen T, Wang L, Zhang C
bioRxiv
. 2024 Jan;
PMID: 38168285
Microglia, as the immune cells of the central nervous system (CNS), play dynamic roles in both health and diseased conditions. The ability to genetically target microglia using viruses is crucial...
4.
Yu Y, Shen T, Zhong X, Wang L, Tai W, Zou Y, et al.
Glia
. 2021 Oct;
70(2):273-286.
PMID: 34643969
In response to brain injury, resident astrocytes become reactive and play dynamic roles in neural repair and regeneration. The signaling pathways underlying such reactive astrogliosis remain largely unclear. We here...
5.
Su L, Xia W, Shen T, Liang Q, Wang W, Li H, et al.
Nucleic Acids Res
. 2018 Jul;
46(17):8817-8831.
PMID: 29982651
Astrocytes play crucial roles in the central nervous system, and defects in astrocyte function are closely related to many neurological disorders. Studying the mechanism of gliogenesis has important implications for...
6.
Shen T, Ji F, Wang Y, Lei X, Zhang D, Jiao J
Nucleic Acids Res
. 2018 Jan;
46(5):2290-2307.
PMID: 29294103
Defects in neurogenesis alter brain circuit formations and may lead to neurodevelopmental disorders such as autism and schizophrenia. Histone H2A.z, a variant of histone H2A, plays critical roles in chromatin...
7.
Ji F, Shen T, Zou W, Jiao J
Stem Cells
. 2017 Mar;
35(6):1479-1492.
PMID: 28276603
Mitochondrial metabolism is a fundamental process in tissue development. How this process play functions in embryonic neurogenesis remains largely unknown. Here, we show that mitochondrial uncoupling protein 2 (UCP2) regulates...
8.
Wang S, Liang Q, Qiao H, Li H, Shen T, Ji F, et al.
Development
. 2016 Jun;
143(15):2732-40.
PMID: 27287808
Disrupted in schizophrenia 1 (DISC1) is known as a high susceptibility gene for schizophrenia. Recent studies have indicated that schizophrenia might be caused by glia defects and dysfunction. However, there...
9.
Shen T, Ji F, Yuan Z, Jiao J
Stem Cells
. 2015 Mar;
33(6):1794-806.
PMID: 25786798
Chromodomain helicase DNA-binding protein 2 (CHD2) has been associated with a broad spectrum of neurodevelopmental disorders, such as autism spectrum disorders and intellectual disability. However, it is largely unknown whether...
10.
Shi Z, Shen T, Liu Y, Huang Y, Jiao J
J Biol Chem
. 2014 Jan;
289(10):6415-6428.
PMID: 24459144
Somatic cells can be reprogrammed to neurons and various other cell types with retrovirus or lentivirus. The limitation of this technology is that these genome-integration viruses may increase the risk...