Thorsten Melcher
Overview
Explore the profile of Thorsten Melcher including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
486
Followers
0
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Recent Articles
1.
Shirvani S, Huntzinger C, Melcher T, Olcott P, Voronenko Y, Bartlett-Roberto J, et al.
Br J Radiol
. 2020 Oct;
94(1117):20200873.
PMID: 33112685
The emerging biological understanding of metastatic cancer and proof-of-concept clinical trials suggest that debulking all gross disease holds great promise for improving patient outcomes. However, ablation of multiple targets with...
2.
Sharma R, Plummer R, Stock J, Greenhalgh T, Ataman O, Kelly S, et al.
Nat Rev Clin Oncol
. 2016 Jun;
13(10):627-42.
PMID: 27245279
In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy as part of their treatment, which is one of the most cost-effective cancer treatments. Notably, around 40%...
3.
Chitneni S, Bida G, Yuan H, Palmer G, Hay M, Melcher T, et al.
J Nucl Med
. 2013 Jun;
54(8):1339-46.
PMID: 23740105
Unlabelled: Hypoxia is a significant therapeutic problem for solid tumors because hypoxic cells are treatment-resistant and more aggressive. Hypoxia-activated prodrugs such as SN30000 use a mechanism of activation in hypoxic...
4.
Froestl W, Gallagher M, Jenkins H, Madrid A, Melcher T, Teichman S, et al.
Biochem Pharmacol
. 2004 Sep;
68(8):1479-87.
PMID: 15451390
The GABA(B) receptor antagonist SGS742 (CGP36742) displays pronounced cognition enhancing effects in mice, young and old rats and in Rhesus monkeys in active and passive avoidance paradigms, in an eight-arm...
5.
Muller S, Kunkel P, Lamszus K, Ulbricht U, Lorente G, Nelson A, et al.
Oncogene
. 2003 Oct;
22(43):6661-8.
PMID: 14555979
Glioblastomas (GBM) are the most frequent and malignant human brain tumor type. Typically striking in adulthood, tumor progression is rapid, relentless, and ultimately leads to the patient's death within a...
6.
Mattiasson G, Shamloo M, Gido G, Mathi K, Tomasevic G, Yi S, et al.
Nat Med
. 2003 Jul;
9(8):1062-8.
PMID: 12858170
Whereas uncoupling protein 1 (UCP-1) is clearly involved in thermogenesis, the role of UCP-2 is less clear. Using hybridization, cloning techniques and cDNA array analysis to identify inducible neuroprotective genes,...