Thomas Weide
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Explore the profile of Thomas Weide including associated specialties, affiliations and a list of published articles.
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55
Citations
4093
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Recent Articles
1.
Schughart K, Moller-Kerutt A, Hoffken V, Nedvetsky P, Groh A, Braun D, et al.
BMC Genom Data
. 2024 Nov;
25(1):102.
PMID: 39614182
In epithelia, apicobasal cell polarization is closely linked to cell-cell contact formation, both controlled by the conserved Crumbs (CRB) complex, which includes the transmembrane protein Crumbs (CRB3a) and adapter proteins...
2.
Groh A, Moller-Kerutt A, Gilhaus K, Hoffken V, Nedvetsky P, Kleimann S, et al.
J Cell Sci
. 2024 Jan;
137(5).
PMID: 38265145
The evolutionarily conserved apical Crumbs (CRB) complex, consisting of the core components CRB3a (an isoform of CRB3), PALS1 and PATJ, plays a key role in epithelial cell-cell contact formation and...
3.
Fiedler J, Moennig T, Hinrichs J, Weber A, Wagner T, Hemmer T, et al.
Cell Mol Life Sci
. 2023 Oct;
80(11):333.
PMID: 37878054
The conserved multiple PDZ-domain containing protein PATJ stabilizes the Crumbs-Pals1 complex to regulate apical-basal polarity and tight junction formation in epithelial cells. However, the molecular mechanism of PATJ's function in...
4.
Junge T, Brendgen R, Grassmann C, Weide T, Schwarz-Pfeiffer A
Sensors (Basel)
. 2023 Aug;
23(16).
PMID: 37631613
A person's body temperature is an important indicator of their health status. A deviation of that temperature by just 2 °C already has or can lead to serious consequences, such...
5.
Grampp S, Kruger R, Lauer V, Uebel S, Knaup K, Naas J, et al.
Kidney Int
. 2023 Apr;
104(1):53-60.
PMID: 37098381
Individuals of African ancestry carrying two pathogenic variants of apolipoprotein 1 (APOL1) have a substantially increased risk for developing chronic kidney disease. The course of APOL1 nephropathy is extremely heterogeneous...
6.
Voing K, Michgehl U, Mertens N, Picciotto C, Maywald M, Goretzko J, et al.
J Am Soc Nephrol
. 2023 Apr;
34(7):1191-1206.
PMID: 37022133
Significance Statement: Endocytosis, recycling, and degradation of proteins are essential functions of mammalian cells, especially for terminally differentiated cells with limited regeneration rates and complex morphology, such as podocytes. To...
7.
Krausel V, Pund L, Nusse H, Bachir H, Ricker A, Klingauf J, et al.
Kidney Int
. 2023 Jan;
103(5):872-885.
PMID: 36587794
Mutations in OSGEP and four other genes that encode subunits of the KEOPS complex cause Galloway-Mowat syndrome, a severe, inherited kidney-neurological disease. The complex catalyzes an essential posttranscriptional modification of...
8.
Loss of surface transport is a main cellular pathomechanism of CRB2 variants causing podocytopathies
Moller-Kerutt A, Schonhoff B, Rellmann Y, George B, Braun D, Pavenstadt H, et al.
Life Sci Alliance
. 2022 Dec;
6(3).
PMID: 36549870
Crumbs2 (CRB2) is a central component of the renal filtration barrier and part of the slit diaphragm, a unique cell contact formed by glomerular podocytes. Some variants cause recessive inherited...
9.
Berghaus C, Groh A, Breljak D, Ciarimboli G, Sabolic I, Pavenstadt H, et al.
Front Mol Biosci
. 2022 Mar;
9:792829.
PMID: 35252349
Pals1 is part of the evolutionary conserved Crumbs polarity complex and plays a key role in two processes, the formation of apicobasal polarity and the establishment of cell-cell contacts. In...
10.
Jehn U, Bayraktar S, Pollmann S, Van Marck V, Weide T, Pavenstadt H, et al.
Int J Mol Sci
. 2021 Nov;
22(21).
PMID: 34768768
Fabry disease (FD) is caused by mutations in the α-galactosidase A () gene encoding the lysosomal AGAL enzyme. Loss of enzymatic AGAL activity and cellular accumulation of sphingolipids (mainly globotriaosylcermide)...