Thomas W Klein
Overview
Explore the profile of Thomas W Klein including associated specialties, affiliations and a list of published articles.
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34
Citations
1372
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Recent Articles
11.
Newton C, Chou P, Perkins I, Klein T
J Neuroimmune Pharmacol
. 2008 Sep;
4(1):92-102.
PMID: 18792785
Legionella pneumophila infection of mice induces proinflammatory cytokines and Th1 immunity as well as rapid increases in serum levels of IL-12 and IFNgamma and splenic IL-12Rbeta2 expression. Delta-9-tetrahydrocannabinol (THC) treatment...
12.
Klein T, Peterson P, Cabral G, Kaminski N, Adler M
J Neuroimmune Pharmacol
. 2008 Aug;
3(4):201-2.
PMID: 18720014
No abstract available.
13.
Agudelo M, Newton C, Widen R, Sherwood T, Nong L, Friedman H, et al.
J Neuroimmune Pharmacol
. 2008 Feb;
3(1):35-42.
PMID: 18247126
Marijuana cannabinoid treatment increases Th2 activity, and previous reports showed that B cells express the highest level of CB(2) mRNA relative to other immune cells, suggesting that cannabinoids play a...
14.
Klein T, Cabral G
J Neuroimmune Pharmacol
. 2007 Nov;
1(1):50-64.
PMID: 18040791
The study of marijuana cannabinoid biology has led to many important discoveries in neuroscience and immunology. These studies have uncovered a new physiological system, the endocannabinoid system, which operates in...
15.
Klein T, Newton C
Adv Exp Med Biol
. 2007 Aug;
601:395-413.
PMID: 17713029
Cannabinoid-based drugs modeled on cannabinoids originally isolated from marijuana are now known to significantly impact the functioning of the endocannabinoid system of mammals. This system operates not only in the...
16.
Mamata Y, Hakki A, Newton C, Burdash N, Klein T, Friedman H
Int J Med Microbiol
. 2007 Feb;
297(2):109-15.
PMID: 17280867
Continuous cultures of human lymphocyte- and monocyte-derived cell lines were examined for levels of immunoregulatory cytokines important in resistance to the intracellular opportunistic bacterium Chlamydia pneumoniae (Cp), a ubiquitous pathogen...
17.
Newton C, Perkins I, Widen R, Friedman H, Klein T
Infect Immun
. 2006 Oct;
75(1):146-51.
PMID: 17060467
The progression of Legionella pneumophila infection in macrophages is controlled by the Lgn1 gene locus, which expresses the nonpermissive phenotype in cells from BALB/c mice but the permissive phenotype in...
18.
Friedman H, Pross S, Klein T
FEMS Immunol Med Microbiol
. 2006 Jul;
47(3):330-42.
PMID: 16872369
The use of drugs of abuse, both recreationally and medicinally, may be related to serious public health concerns. There is a relationship between addictive drugs of abuse such as alcohol...
19.
Lu T, Newton C, Perkins I, Friedman H, Klein T
J Pharmacol Exp Ther
. 2006 Jul;
319(1):269-76.
PMID: 16837556
Marijuana cannabinoids, such as delta-9-tetrahydrocannabinoid (THC), suppress type 1 T-helper 1 (Th1) immunity in a variety of models, including infection with the intracellular pathogen Legionella pneumophila (Lp). To examine the...
20.
Lu T, Newton C, Perkins I, Friedman H, Klein T
Eur J Pharmacol
. 2006 Jan;
532(1-2):170-7.
PMID: 16443217
Delta-9-tetrahydrocannabinol (THC) injection suppresses serum interleukin-12 (IL-12) levels in Legionella pneumophila-infected mice. Dendritic cells are a major producer of IL-12 and mouse, bone marrow-derived dendritic cell cultures produced high levels...