Thomas Seeger
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Explore the profile of Thomas Seeger including associated specialties, affiliations and a list of published articles.
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79
Citations
238
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Recent Articles
1.
Springer F, Freisleben M, Muschik S, Worek F, Seeger T, Meinel L, et al.
Toxicol Lett
. 2025 Jan;
404:58-66.
PMID: 39805477
The nicotinic acetylcholine receptor (nAChR) is a pentameric ligand-gated ion channel (pLGIC) commonly used as a model for receptors belonging to the Cys-loop superfamily. Members of pLGICs are standardly used...
2.
Springer F, Freisleben M, Muschik S, Kohl M, Worek F, Meinel L, et al.
Toxicol Lett
. 2024 Sep;
401:108-115.
PMID: 39276811
The therapy of intoxication with distinct organophosphorus (OP) compounds is still limited today. Especially chemical warfare agents like tabun and soman as well as novichok intoxications are difficult to address...
3.
Brockmoller S, Seeger T, Worek F, Rothmiller S
Cells
. 2024 Sep;
13(17.
PMID: 39273021
Background: Intracellular tracking is commonly used in trafficking research. Until today, the respective techniques have remained complex, and complicated, mostly transgenic target protein changes are necessary, often requiring expensive equipment...
4.
Brockmoller S, Molitor L, Seeger T, Worek F, Rothmiller S
J Membr Biol
. 2024 Jul;
257(3-4):245-256.
PMID: 38967800
The human neuronal nicotinic acetylcholine receptor α7 (nAChR) is an important target implicated in diseases like Alzheimer's or Parkinson's, as well as a validated target for drug discovery. For α7...
5.
Kaiser J, Gertzen C, Bernauer T, Nitsche V, Hofner G, Niessen K, et al.
Toxicol Lett
. 2024 May;
398:91-104.
PMID: 38768836
Desensitization of nicotinic acetylcholine receptors (nAChRs) can be induced by overstimulation with acetylcholine (ACh) caused by an insufficient degradation of ACh after poisoning with organophosphorus compounds (OPCs). Currently, there is...
6.
Bernauer T, Nitsche V, Kaiser J, Gertzen C, Hofner G, Niessen K, et al.
Toxicol Lett
. 2024 May;
397:151-162.
PMID: 38759939
Poisoning with organophosphorus compounds, which can lead to a cholinergic crisis due to the inhibition of acetylcholinesterase and the subsequent accumulation of acetylcholine (ACh) in the synaptic cleft, is a...
7.
Amend N, Timperley C, Bird M, Green A, Worek F, Seeger T
Toxicol Lett
. 2024 May;
397:42-47.
PMID: 38723915
Organophosphate pesticide poisoning challenges health care systems worldwide. Furthermore, nerve agents remain a continuous threat. The treatment options for organophosphate poisoning have virtually been unchanged for decades, relying on symptomatic...
8.
Wultschner J, Schmitz I, Revidat S, Ullrich J, Seeger T
Sensors (Basel)
. 2024 Apr;
24(8).
PMID: 38676076
Due to a rising importance of the reduction of pollutant, produced by conventional energy technologies, the knowledge of pollutant forming processes during a combustion is of great interest. In this...
9.
Sichler S, Hofner G, Nitsche V, Niessen K, Seeger T, Worek F, et al.
Toxicol Lett
. 2024 Feb;
394:23-31.
PMID: 38387764
Intoxications with organophosphorus compounds (OPCs) effect a severe impairment of cholinergic neurotransmission that, as a result of overstimulation may lead to desensitization of nicotinic acetylcholine receptors (nAChRs) and finally to...
10.
Amend N, Timperley C, Bird M, Green A, Worek F, Seeger T
Toxicology
. 2024 Feb;
503:153741.
PMID: 38311098
Organophosphate (OP) poisoning is currently treated with atropine, oximes and benzodiazepines. The nicotinic signs, i.e., respiratory impairment, can only be targeted indirectly via the use of oximes as reactivators of...