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Thomas R Weikl

Explore the profile of Thomas R Weikl including associated specialties, affiliations and a list of published articles. Areas
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Articles 62
Citations 1552
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Recent Articles
1.
Bonazzi F, Weikl T
Nanoscale . 2025 Feb; 17(11):6841-6853. PMID: 39964755
Besides direct molecular interactions, proteins and nanoparticles embedded in or adsorbed to membranes experience indirect interactions that are mediated by the membranes. Membrane-mediated interactions between curvature-inducing proteins or nanoparticles can...
2.
Kullmann R, Delbianco M, Roth C, Weikl T
J Phys Chem B . 2024 Nov; 128(49):12114-12121. PMID: 39589929
Naturally occurring cellulose Iβ with its characteristic parallel orientation of cellulose chains is less stable than cellulose II, in which neighboring pairs of chains are oriented antiparallel to each other....
3.
Azadbakht A, Weikl T, Kraft D
ACS Nano . 2024 Aug; 18(34):23067-23076. PMID: 39145618
Membrane-induced interactions play an important role in organizing membrane proteins. Measurements of the interactions between two and three membrane deforming objects have revealed their nonadditive nature. They are thought to...
4.
Gao J, Hou R, Hu W, Weikl T, Hu J
J Phys Chem B . 2024 May; 128(19):4735-4740. PMID: 38706129
Arc-shaped BIN/Amphiphysin/Rvs (BAR) domain proteins generate curvature by binding to membranes and induce membrane tubulation at sufficiently large protein coverages. For the amphiphysin N-BAR domain, Le Roux et al., ,...
5.
Groza R, Schmidt K, Muller P, Ronchi P, Schlack-Leigers C, Neu U, et al.
Nat Commun . 2024 Mar; 15(1):2767. PMID: 38553473
Several bacterial toxins and viruses can deform membranes through multivalent binding to lipids for clathrin-independent endocytosis. However, it remains unclear, how membrane deformation and endocytic internalization are mechanistically linked. Here...
6.
Asadollahi K, Rajput S, de Zhang L, Ang C, Nie S, Williamson N, et al.
Nat Commun . 2023 Dec; 14(1):8155. PMID: 38071229
The conformational ensembles of G protein-coupled receptors (GPCRs) include inactive and active states. Spectroscopy techniques, including NMR, show that agonists, antagonists and other ligands shift the ensemble toward specific states...
7.
Groza R, Schmidt K, Muller P, Ronchi P, Schlack-Leigers C, Neu U, et al.
bioRxiv . 2023 Jul; PMID: 37503169
Several bacterial toxins and viruses can deform membranes through multivalent binding to lipids for clathrin-independent endocytosis. However, it remains unclear, how membrane deformation and endocytic internalization are mechanistically linked. Here...
8.
Kav B, Weikl T, Schneck E
J Phys Chem B . 2023 May; 127(18):4081-4089. PMID: 37127845
Binding forces between biomolecules are ubiquitous in nature but sometimes as weak as a few pico-Newtons (pN). In many cases, the binding partners are attached to biomembranes with the help...
9.
Pandey P, Rozycki B, Weikl T
Methods Mol Biol . 2023 Apr; 2654:51-59. PMID: 37106175
Molecular dynamics simulations of immune receptor and ligand proteins in their native membrane environment allow to determine the orientational and structural variability of the proteins and protein complexes. The simulations...
10.
Pettmann J, Awada L, Rozycki B, Huhn A, Faour S, Kutuzov M, et al.
EMBO J . 2022 Dec; 42(7):e111841. PMID: 36484367
T cells use their T-cell receptors (TCRs) to discriminate between lower-affinity self and higher-affinity foreign peptide major-histocompatibility-complexes (pMHCs) based on the TCR/pMHC off-rate. It is now appreciated that T cells...