Thomas R Shannon
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Explore the profile of Thomas R Shannon including associated specialties, affiliations and a list of published articles.
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29
Citations
1762
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Recent Articles
1.
R Shannon T, Michael J
Adv Physiol Educ
. 2023 Aug;
47(4):796-800.
PMID: 37615042
The maintenance of a more or less constant internal environment by homeostatic (negative feedback) mechanisms is well understood, and "homeostasis" is regarded as an important core concept for students to...
2.
R Shannon T, Bare D, Van Dijk S, Raofi S, Huynh T, Xiang Y, et al.
Function (Oxf)
. 2022 May;
3(3):zqac020.
PMID: 35620477
β-adrenergic receptor (β-AR) signaling in cardiac myocytes is central to cardiac function, but spatiotemporal activation within myocytes is unresolved. In rabbit ventricular myocytes, β-AR agonists or high extracellular [Ca] were...
3.
Pereira L, Bare D, Galice S, R Shannon T, Bers D
J Mol Cell Cardiol
. 2017 May;
108:8-16.
PMID: 28476660
Cardiac β-adrenergic receptors (β-AR) and Ca-Calmodulin dependent protein kinase (CaMKII) regulate both physiological and pathophysiological Ca signaling. Elevated diastolic Ca leak from the sarcoplasmic reticulum (SR) contributes to contractile dysfunction...
4.
Berti C, Zsolnay V, R Shannon T, Fill M, Gillespie D
J Mol Cell Cardiol
. 2016 Dec;
103:31-39.
PMID: 27914790
During systole, Ca is released from the sarcoplasmic reticulum (SR) through ryanodine receptors (RyRs) while, simultaneously, other ions (specifically K, Mg, and Cl) provide counter-ion flux. These ions move back...
5.
Hegyi B, Banyasz T, R Shannon T, Chen-Izu Y, Izu L
Biophys J
. 2016 Sep;
111(6):1304-1315.
PMID: 27653489
In the heart, Na(+) is a key modulator of the action potential, Ca(2+) homeostasis, energetics, and contractility. Because Na(+) currents and cotransport fluxes depend on the Na(+) concentration in the...
6.
Sato D, R Shannon T, Bers D
Biophys J
. 2016 Jan;
110(2):382-390.
PMID: 26789761
Calcium (Ca) sparks are the fundamental sarcoplasmic reticulum (SR) Ca release events in cardiac myocytes, and they have a typical duration of 20-40 ms. However, when a fraction of ryanodine...
7.
Curran J, Tang L, Roof S, Velmurugan S, Millard A, Shonts S, et al.
PLoS One
. 2014 Feb;
9(2):e87495.
PMID: 24498331
Spontaneous calcium waves in cardiac myocytes are caused by diastolic sarcoplasmic reticulum release (SR Ca(2+) leak) through ryanodine receptors. Beta-adrenergic (β-AR) tone is known to increase this leak through the...
8.
Santiago D, Rios E, R Shannon T
Biophys J
. 2013 Mar;
104(5):976-85.
PMID: 23473480
Recent research suggests that the diastolic ryanodine-receptor-mediated release of Ca(2+) (J(leak)) from the sarcoplasmic reticulum of ventricular myocytes occurs in spark and nonspark forms. Further information about the role(s) of...
9.
Bers D, R Shannon T
J Mol Cell Cardiol
. 2013 Jan;
58:59-66.
PMID: 23321551
Sarcoplasmic reticulum (SR) Ca content ([Ca]SRT) is critical to both normal cardiac function and electrophysiology, and changes associated with pathology contribute to systolic and diastolic dysfunction and arrhythmias. The intra-SR...
10.
Edwards J, Cully T, R Shannon T, Stephenson D, Launikonis B
J Physiol
. 2011 Dec;
590(3):475-92.
PMID: 22155929
Mammalian skeletal muscle fibres possess a tubular (t-) system that consists of regularly spaced transverse elements which are also connected in the longitudinal direction. This tubular network provides a pathway...