Thomas Mortimer
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Explore the profile of Thomas Mortimer including associated specialties, affiliations and a list of published articles.
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11
Citations
120
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Recent Articles
1.
Duan J, Karri S, Forouzesh K, Mortimer T, Plikus M, Benitah S, et al.
J Invest Dermatol
. 2025 Feb;
145(3):484-493.
PMID: 39891645
All skin layers and cutaneous appendages harbor a robust circadian clock, whose phase is under the influence of light through the central clock in the suprachiasmatic nucleus. The skin clock...
2.
Mortimer T, Smith J, Munoz-Canoves P, Benitah S
Nat Rev Mol Cell Biol
. 2025 Jan;
PMID: 39753699
Maintaining homeostasis is essential for continued health, and the progressive decay of homeostatic processes is a hallmark of ageing. Daily environmental rhythms threaten homeostasis, and circadian clocks have evolved to...
3.
Mortimer T, Zinna V, Atalay M, Laudanna C, Deryagin O, Posas G, et al.
Cell Stem Cell
. 2024 May;
31(6):834-849.e4.
PMID: 38701785
In mammals, the circadian clock network drives daily rhythms of tissue-specific homeostasis. To dissect daily inter-tissue communication, we constructed a mouse minimal clock network comprising only two nodes: the peripheral...
4.
Kumar A, Vaca-Dempere M, Mortimer T, Deryagin O, Smith J, Petrus P, et al.
Science
. 2024 May;
384(6695):563-572.
PMID: 38696572
A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice...
5.
Baker K, Bercher O, Twitty J, Mortimer T, Watson M
J Org Chem
. 2023 Jun;
89(22):16249-16252.
PMID: 37368977
A Ni/1-bpp catalyst was demonstrated to be effective in the Negishi alkylation with multiple classes of alkylpyridinium salts, including α-primary and α-secondary. These conditions are also effective for benzylic pyridinium...
6.
Smith J, Koronowski K, Mortimer T, Sato T, Greco C, Petrus P, et al.
Cell Rep
. 2023 Jun;
42(6):112588.
PMID: 37267101
Physiology is regulated by interconnected cell and tissue circadian clocks. Disruption of the rhythms generated by the concerted activity of these clocks is associated with metabolic disease. Here we tested...
7.
Mortimer T
FEBS J
. 2022 Oct;
289(21):6640-6642.
PMID: 36271686
Growing evidence suggests that circadian clock dysfunction may contribute to the pathology of osteoarthritis. In this issue, He et al. use in vivo and human-derived osteoarthritis models to demonstrate the...
8.
Petrus P, Smith J, Koronowski K, Chen S, Sato T, Greco C, et al.
Sci Adv
. 2022 Jun;
8(26):eabo2896.
PMID: 35767612
Life on Earth anticipates recurring 24-hour environmental cycles via genetically encoded molecular clocks active in all mammalian organs. Communication between these clocks controls circadian homeostasis. Intertissue communication is mediated, in...
9.
Greco C, Koronowski K, Smith J, Shi J, Kunderfranco P, Carriero R, et al.
Sci Adv
. 2021 Sep;
7(39):eabi7828.
PMID: 34550736
The mammalian circadian clock, expressed throughout the brain and body, controls daily metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for this task. Because of the...
10.
Mortimer T, Welz P, Benitah S, Koronowski K
STAR Protoc
. 2021 May;
2(2):100539.
PMID: 34036284
Molecular daily rhythms can be captured by precisely timed tissue harvests from groups of animals. This protocol will allow the investigator to identify transcriptional rhythms in the mouse liver while...