Thomas M Stubbs
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Explore the profile of Thomas M Stubbs including associated specialties, affiliations and a list of published articles.
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12
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916
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Recent Articles
1.
Schmunk L, Call T, McCartney D, Javaid H, Hastings W, Jovicevic V, et al.
Aging Cell
. 2025 Jan;
:e14444.
PMID: 39888134
Accessible and non-invasive biomarkers that measure human ageing processes and the risk of developing age-related disease are paramount in preventative healthcare. Here, we describe a novel framework to train saliva-based...
2.
Bonder M, Clark S, Krueger F, Luo S, Agostinho de Sousa J, Hashtroud A, et al.
Nat Commun
. 2024 Aug;
15(1):7567.
PMID: 39217176
Ageing is the accumulation of changes and decline of function of organisms over time. The concept and biomarkers of biological age have been established, notably DNA methylation-based clocks. The emergence...
3.
Gill D, Parry A, Santos F, Okkenhaug H, Todd C, Hernando-Herraez I, et al.
Elife
. 2022 Apr;
11.
PMID: 35390271
Ageing is the gradual decline in organismal fitness that occurs over time leading to tissue dysfunction and disease. At the cellular level, ageing is associated with reduced function, altered gene...
4.
Evano B, Gill D, Hernando-Herraez I, Comai G, Stubbs T, Commere P, et al.
PLoS Genet
. 2020 Oct;
16(10):e1009022.
PMID: 33125370
Adult skeletal muscles are maintained during homeostasis and regenerated upon injury by muscle stem cells (MuSCs). A heterogeneity in self-renewal, differentiation and regeneration properties has been reported for MuSCs based...
5.
Martin-Herranz D, Aref-Eshghi E, Bonder M, Stubbs T, Choufani S, Weksberg R, et al.
Genome Biol
. 2019 Aug;
20(1):146.
PMID: 31409373
Background: Epigenetic clocks are mathematical models that predict the biological age of an individual using DNA methylation data and have emerged in the last few years as the most accurate...
6.
Hahn O, Stubbs T, Reik W, Gronke S, Beyer A, Partridge L
PLoS Genet
. 2018 Nov;
14(11):e1007766.
PMID: 30462643
Dietary, pharmacological and genetic interventions can extend health- and lifespan in diverse mammalian species. DNA methylation has been implicated in mediating the beneficial effects of these interventions; methylation patterns deteriorate...
7.
Clark S, Argelaguet R, Kapourani C, Stubbs T, Lee H, Alda-Catalinas C, et al.
Nat Commun
. 2018 Feb;
9(1):781.
PMID: 29472610
Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory relationships, including epigenome-transcriptome interactions. Here, we report a single-cell method for parallel chromatin accessibility, DNA methylation and transcriptome profiling. scNMT-seq...
8.
Martin-Herranz D, Ribeiro A, Krueger F, Thornton J, Reik W, Stubbs T
Nucleic Acids Res
. 2017 Oct;
45(20):11559-11569.
PMID: 29036576
DNA methylation is an important epigenetic modification in many species that is critical for development, and implicated in ageing and many complex diseases, such as cancer. Many cost-effective genome-wide analyses...
9.
Stubbs T, Bonder M, Stark A, Krueger F, von Meyenn F, Stegle O, et al.
Genome Biol
. 2017 Apr;
18(1):68.
PMID: 28399939
Background: DNA methylation changes at a discrete set of sites in the human genome are predictive of chronological and biological age. However, it is not known whether these changes are...
10.
Hahn O, Gronke S, Stubbs T, Ficz G, Hendrich O, Krueger F, et al.
Genome Biol
. 2017 Mar;
18(1):56.
PMID: 28351387
Background: Dietary restriction (DR), a reduction in food intake without malnutrition, increases most aspects of health during aging and extends lifespan in diverse species, including rodents. However, the mechanisms by...