Thomas M Razler
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Explore the profile of Thomas M Razler including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Beutner G, Carrasquillo R, Geng P, Hsiao Y, Huang E, Janey J, et al.
Org Lett
. 2018 Jun;
20(13):3736-3740.
PMID: 29909639
A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound 1A with complete stereocontrol, is reported.
2.
Hartley R, Huang Y, Cassidy M, Razler T, Qian F, Hussain M
J Pharm Sci
. 2012 Jan;
101(9):3124-33.
PMID: 22262489
The stability of a 1,2,4-oxadiazole derivative, BMS-708163, A, was studied in the cosolvent mixture of acetonitrile-water at various pH values, in the solid state and in the presence of various...
3.
Smith 3rd A, Hogan A, Liu Z, Razler T, Meis R, Morinaka B, et al.
Tetrahedron
. 2011 Aug;
67(27-28):5069-5078.
PMID: 21811346
The design, synthesis and biological evaluation of a new phorboxazole analogue, comprising an acetal replacement for the C-ring tetrahdropyran of the natural product and carrying a potency-enhancing C(45-46) vinyl chloride...
4.
Razler T, Hsiao Y, Qian F, Fu R, Khan R, Doubleday W
J Org Chem
. 2009 Jan;
74(3):1381-4.
PMID: 19178357
A ligand-free Suzuki-Miyaura reaction for the cross-coupling of aryl and heteroaryl bromides with aryl and heteroarylboronic acids has been developed utilizing catalytic polyethylene glycol 2000 (PEG 2000). This preparatively convenient...
5.
Smith 3rd A, Fox R, Razler T
Acc Chem Res
. 2008 May;
41(5):675-87.
PMID: 18489082
The frequent low abundance of architecturally complex natural products possessing significant bioregulatory properties mandates the development of rapid, efficient, and stereocontrolled synthetic tactics, not only to provide access to the...
6.
Smith 3rd A, Razler T, Meis R, Pettit G
J Org Chem
. 2008 Jan;
73(4):1201-8.
PMID: 18215059
Highly convergent syntheses of eight phorboxazole congeners and their evaluation against a diverse panel of human solid tumor cancer cell lines have been achieved. Specifically, the C(45-46) alkyne, alkene, and...
7.
Smith 3rd A, Razler T, Ciavarri J, Hirose T, Ishikawa T, Meis R
J Org Chem
. 2008 Jan;
73(4):1192-200.
PMID: 18215058
A highly convergent second-generation synthesis of (+)-phorboxazole A has been achieved. Highlights of the synthetic approach include improved Petasis-Ferrier union/rearrangement conditions on a scale to assemble multigram quantities of the...
8.
Smith 3rd A, Razler T, Meis R, Pettit G
Org Lett
. 2006 Feb;
8(4):797-9.
PMID: 16468770
[structure: see text] We disclose here the design, synthesis, and biological evaluation of simplified Z- and E-C(2-3) alkynyl phorboxazole C(11-15) acetals (+)-7Z and (+)-7E, wherein the Z-isomer proved to be...
9.
Smith 3rd A, Razler T, Pettit G, Chapuis J
Org Lett
. 2005 Sep;
7(20):4403-6.
PMID: 16178544
[structure: see text] Effective, scalable total syntheses and biological evaluation of six phorboxazole A analogues (1-6) have been achieved. Importantly, the C(45-46)-saturated, C(45-46)-alkenyl, and the C(45-46)-E-chloroalkenyl congeners (4, 5, and...
10.
Smith 3rd A, Razler T, Ciavarri J, Hirose T, Ishikawa T
Org Lett
. 2005 Sep;
7(20):4399-402.
PMID: 16178543
[structure: see text] A second generation total synthesis of the potent antitumor agent (+)-phorboxazole A (1) has been achieved. The cornerstone of this approach comprises a more convergent strategy, involving...