Thomas J Sick
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Explore the profile of Thomas J Sick including associated specialties, affiliations and a list of published articles.
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19
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721
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Recent Articles
1.
Blaya M, Wasserman J, Pieper A, Sick T, Bramlett H, Dietrich W
Neuropharmacology
. 2018 Sep;
145(Pt B):268-282.
PMID: 30236963
Traumatic brain injury (TBI) is a significant public health problem around the world. A promising area of research is the characterization of small, drug-like molecules that have potent clinical properties....
2.
Perez E, Tapanes S, Loris Z, Balu D, Sick T, Coyle J, et al.
J Clin Invest
. 2017 Jul;
127(8):3114-3125.
PMID: 28714867
After traumatic brain injury (TBI), glial cells have both beneficial and deleterious roles in injury progression and recovery. However, few studies have examined the influence of reactive astrocytes in the...
3.
Perez E, Cepero M, Perez S, Coyle J, Sick T, Liebl D
Neurobiol Dis
. 2016 Jun;
94:73-84.
PMID: 27317833
Traumatic brain injury (TBI), ranging from mild concussion to severe penetrating wounds, can involve brain regions that contain damaged or lost synapses in the absence of neuronal death. These affected...
4.
Morris-Blanco K, Cohan C, Neumann J, Sick T, Perez-Pinzon M
J Cereb Blood Flow Metab
. 2014 Mar;
34(6):1024-32.
PMID: 24667915
Preserving mitochondrial pools of nicotinamide adenine dinucleotide (NAD) or nicotinamide phosphoribosyltransferase (Nampt), an enzyme involved in NAD production, maintains mitochondrial function and confers neuroprotection after ischemic stress. However, the mechanisms...
5.
Raval A, Borges-Garcia R, Diaz F, Sick T, Bramlett H
Transl Stroke Res
. 2013 Dec;
4(4):402-12.
PMID: 24323338
Oral contraceptives (OC) and smoking-derived nicotine (N) are known to synergistically increase the risk and severity of cerebral ischemia in women. Although it has been known for some time that...
6.
Titus D, Sakurai A, Kang Y, Furones C, Jergova S, Santos R, et al.
J Neurosci
. 2013 Mar;
33(12):5216-26.
PMID: 23516287
Traumatic brain injury (TBI) modulates several cell signaling pathways in the hippocampus critical for memory formation. Previous studies have found that the cAMP-protein kinase A signaling pathway is downregulated after...
7.
Raval A, Sick J, Gonzalez G, DeFazio R, Dong C, Sick T
Neurosci Lett
. 2012 Apr;
517(1):41-6.
PMID: 22521583
Nicotine, the addictive agent in cigarettes, reduces circulating estradiol-17β (E₂) and inhibits E₂-mediated intracellular signaling in hippocampus of female rats. In hippocampus, E₂-signaling regulates synaptic plasticity by phosphorylation of the...
8.
Zhuang Z, Yang B, Theus M, Sick J, Bethea J, Sick T, et al.
J Neurosci
. 2010 Nov;
30(47):16015-24.
PMID: 21106840
There is growing evidence that astrocytes play critical roles in neuron-glial interactions at the synapse. Astrocytes are believed to regulate presynaptic and postsynaptic structures and functions, in part, by the...
9.
Atkins C, Truettner J, Lotocki G, Sanchez-Molano J, Kang Y, Alonso O, et al.
Eur J Neurosci
. 2010 Nov;
32(11):1912-20.
PMID: 21044182
Traumatic brain injury (TBI) is a major risk factor for the subsequent development of epilepsy. Currently, chronic seizures after brain injury are often poorly controlled by available antiepileptic drugs. Hypothermia...
10.
Binder D, Yao X, Zador Z, Sick T, Verkman A, Manley G
Glia
. 2006 Feb;
53(6):631-6.
PMID: 16470808
The glial water channel aquaporin-4 (AQP4) has been hypothesized to modulate water and potassium fluxes associated with neuronal activity. In this study, we examined the seizure phenotype of AQP4 -/-...